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Antazoline hydrochloride

Name: Antazoline hydrochloride
Brand: TargetMol
SKU: T0092
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0092Cas No. 2508-72-7

Alias Phenazoline hydrochloride, Phenazocine HCl, Antazoline HCl

Antazoline hydrochloride (Phenazoline hydrochloride), a first-generation antihistamine, can bind to the histamine H1 receptor and block the action of endogenous histamine.

Antazoline hydrochloride

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Purity: 99.53%

Catalog No. T0092Alias Phenazoline hydrochloride, Phenazocine HCl, Antazoline HClCas No. 2508-72-7

Antazoline hydrochloride (Phenazoline hydrochloride), a first-generation antihistamine, can bind to the histamine H1 receptor and block the action of endogenous histamine.

Pack Size	Price	USA Warehouse	Global Warehouse
500 mg	$30	In Stock	In Stock
1 g	$48	In Stock	In Stock
2 g	$68	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.53%

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COA HPLC HNMR LCMS

Product Introduction

Bioactivity

Description	Antazoline hydrochloride (Phenazoline hydrochloride), a first-generation antihistamine, can bind to the histamine H1 receptor and block the action of endogenous histamine.
In vitro	In the model of sustained epileptic state induced by picrotoxin, Antazoline can be utilized to protect the intrinsic neural circuitry.
In vivo	At a concentration of 30 μM, Antazoline effectively reduces neurotoxicity mediated by NMDA and also blocks NMDA-induced currents via a voltage-dependent and rapidly reversible action, with an inhibition rate of 85±3% at a voltage of -60 mV.
Synonyms	Phenazoline hydrochloride, Phenazocine HCl, Antazoline HCl

Chemical Properties

Molecular Weight	301.82
Formula	C₁₇H₁₉N₃·HCl
Cas No.	2508-72-7
Smiles	C(N(Cc1ccccc1)c1ccccc1)C1=NCCN1
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (149.1 mM), Sonication is recommended.

H2O: 14 mg/mL (46.39 mM), Sonication is recommended.

Ethanol: 4 mg/mL (13.25 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2 mg/mL (6.63 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3132 mL	16.5662 mL	33.1323 mL	165.6617 mL
5 mM	0.6626 mL	3.3132 mL	6.6265 mL	33.1323 mL
10 mM	0.3313 mL	1.6566 mL	3.3132 mL	16.5662 mL

H2O/DMSO

	1mg	5mg	10mg	50mg
20 mM	0.1657 mL	0.8283 mL	1.6566 mL	8.2831 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0663 mL	0.3313 mL	0.6626 mL	3.3132 mL
100 mM	0.0331 mL	0.1657 mL	0.3313 mL	1.6566 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc