Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BChE-IN-4 is a highly potent inhibitor of the enzyme butyrylcholinesterase, capable of crossing the blood-brain barrier. It effectively reduces learning and memory impairments resulting from a deficiency in cholinergic activity in a mouse model. BChE-IN-4 holds promise for further investigation in the field of Alzheimer's disease research [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | BChE-IN-4 is a highly potent inhibitor of the enzyme butyrylcholinesterase, capable of crossing the blood-brain barrier. It effectively reduces learning and memory impairments resulting from a deficiency in cholinergic activity in a mouse model. BChE-IN-4 holds promise for further investigation in the field of Alzheimer's disease research [1]. |
In vivo | BChE-IN-4 (compound 1) administered at doses of 10, 20, and 30 mg/kg, effectively mitigates learning and memory impairments associated with cholinergic deficits in an Alzheimer's disease (AD) mouse model, without inducing adverse motor effects at a 30 mg/kg dosage. Studies conducted on adult male Albino Swiss CD-1 mice with scopolamine-induced memory impairments revealed that BChE-IN-4 significantly enhances step-through latencies, indicating an improvement in memory. Additionally, in C57BL/6J mice weighing 18-22 g, a 30 mg/kg dosage did not improve learning abilities or working memory initially or in short-term memory retrieval by day 5; however, it significantly enhanced long-term memory retrieval by day 12 in the Barnes maze task. Further examination in mice at a 30 mg/kg dosage, suspended in 1% Tween 80, affirmed that BChE-IN-4 does not affect locomotor activity nor cause motor deficits in rotarod tests at various speeds, reinforcing its safety and efficacy in improving cognitive functions without impairing motor skills. |
Molecular Weight | 383.57 |
Formula | C24H37N3O |
CAS No. | 2304818-41-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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BChE-IN-4 2304818-41-3 inhibitor inhibit