Powder: -20°C for 3 years | In solvent: -80°C for 1 year
JPS014, a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimera (PROTAC), effectively degrades class I histone deacetylase (HDAC), exhibiting potency as an HDAC1/2 degrader. This correlation is associated with an increase in differentially expressed genes and enhanced apoptosis in HCT116 cells [1].
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Description | JPS014, a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimera (PROTAC), effectively degrades class I histone deacetylase (HDAC), exhibiting potency as an HDAC1/2 degrader. This correlation is associated with an increase in differentially expressed genes and enhanced apoptosis in HCT116 cells [1]. |
Molecular Weight | 854.07 |
Formula | C46H59N7O7S |
CAS No. | 2669785-76-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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JPS014 2669785-76-4 inhibitor inhibit