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Anti-Integrin alpha 6 Antibody (1Z257)

😃Good
Catalog No. TMAB-07744

Anti-Integrin alpha 6 Antibody (1Z257) is a Rabbit antibody targeting Integrin alpha 6. Anti-Integrin alpha 6 Antibody (1Z257) can be used in WB.

Anti-Integrin alpha 6 Antibody (1Z257)

Anti-Integrin alpha 6 Antibody (1Z257)

😃Good
Catalog No. TMAB-07744
Anti-Integrin alpha 6 Antibody (1Z257) is a Rabbit antibody targeting Integrin alpha 6. Anti-Integrin alpha 6 Antibody (1Z257) can be used in WB.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 μL$2617-10 days7-10 days
100 μL$4707-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-Integrin alpha 6 Antibody (1Z257) is a Rabbit antibody targeting Integrin alpha 6. Anti-Integrin alpha 6 Antibody (1Z257) can be used in WB.
Ig Type
IgG
Clone
1Z257
Reactivity
Human,Mouse,Rat
Application
Recommended Dose
WB: 1:500-2000
Antibody Type
Monoclonal
Host SpeciesRabbit
Subcellular LocalizationCell membrane; Single-pass type I membrane protein.
Tissue SpecificityIntegrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoforms containing segment X1 are ubiquitously expressed. Isoforms containing segment X1X2 are expressed in heart, kidney, placenta, colon, duodenum, myoblasts and myotubes, and in a limited number of cell lines; they are always coexpressed with the ubiquitous isoform containing segment X1. In some tissues (e.g. Salivary gland), isoforms containing cytoplasmic segment A and isoforms containing segment B are detected while in others, only isoforms containing one cytoplasmic segment are found (segment A in epidermis and segment B in kidney).
ConstructionRecombinant Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundThe gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit. This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. The alpha 6 beta 4 integrin may promote tumorigenesis, while the alpha 6 beta 1 integrin may negatively regulate erbB2/HER2 signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Antigen Details
Immunogen
A synthesized peptide: human Integrin alpha 6
Antigen Species
Human
Gene Name
ITGA6
Gene ID
Protein Name
Integrin alpha-6
Uniprot ID
Function
Integrin alpha-6/beta-1 is a receptor for laminin on platelets. Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome.
Chemical Properties
Molecular WeightTheoretical: 127 kDa.
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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