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UBE2T/FANCL-IN-1

Catalog No. T38765 CAS 1359415-02-3

Synonyms: UBE2T/FANCL-IN-1

UBE2T/FANCL-IN-1 is a highly effective inhibitor of UBE2T/FANCL-mediated FANCD2 monoubiquitylation. It greatly enhances the sensitivity of cells to Carboplatin, a DNA cross-linking agent.

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UBE2T/FANCL-IN-1, CAS 1359415-02-3

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

UBE2T/FANCL-IN-1 is a highly effective inhibitor of UBE2T/FANCL-mediated FANCD2 monoubiquitylation. It greatly enhances the sensitivity of cells to Carboplatin, a DNA cross-linking agent.

In vitro

UBE2T/FANCL-IN-1 (CU2) effectively prevents GST-FANCLRING ubiquitylation at a concentration of 100 μM. At a higher dosage of 500 μM, it significantly reduces the ubiquitylation of FANCD2 mediated by HU and Cisplatin (10 μM) treatments over timespans of 6, 12, and 24 hours. Furthermore, using 250 μM of UBE2T/FANCL-IN-1 in combination with 15 μM carboplatin markedly inhibits cell proliferation, resulting in less than 50% confluence after 8 days[1].

Synonyms	UBE2T/FANCL-IN-1
Molecular Weight	357.506
Formula	C19H31N7
CAS No.	1359415-02-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Cornwell MJ, et al. Small-Molecule Inhibition of UBE2T/FANCL-Mediated Ubiquitylation in the Fanconi Anemia Pathway. ACS Chem Biol. 2019;14(10):2148-2154.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

UBE2T/FANCL-IN-1 1359415-02-3 UBE-2T/FANCL-IN-1 UBE2T/FANCLIN1 UBE2T/FANCL IN 1 inhibitor inhibit

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