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UBE2T/FANCL-IN-1
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Catalog No. T38765Cas No. 1359415-02-3
Alias UBE2T/FANCL-IN-1
UBE2T/FANCL-IN-1 is a potent inhibitor of UBE2T/FANCL-mediated FANCD2 monoubiquitylation, significantly enhancing cellular sensitivity to Carboplatin, a DNA cross-linking agent.
UBE2T/FANCL-IN-1
🥰Excellent
Catalog No. T38765Alias UBE2T/FANCL-IN-1Cas No. 1359415-02-3
UBE2T/FANCL-IN-1 is a potent inhibitor of UBE2T/FANCL-mediated FANCD2 monoubiquitylation, significantly enhancing cellular sensitivity to Carboplatin, a DNA cross-linking agent.
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Product Introduction
Bioactivity
Chemical Properties
| Description | UBE2T/FANCL-IN-1 is a potent inhibitor of UBE2T/FANCL-mediated FANCD2 monoubiquitylation, significantly enhancing cellular sensitivity to Carboplatin, a DNA cross-linking agent. |
| In vitro | UBE2T/FANCL-IN-1 (CU2) effectively prevents GST-FANCLRING ubiquitylation at 100 μM and significantly reduces FANCD2 ubiquitylation mediated by HU and Cisplatin (10 μM) at 500 μM over 6, 12, and 24 hours. Additionally, 250 μM UBE2T/FANCL-IN-1 combined with 15 μM carboplatin markedly inhibits cell proliferation, resulting in less than 50% confluence after 8 days[1]. |
| Synonyms | UBE2T/FANCL-IN-1 |
| Molecular Weight | 357.506 |
| Formula | C19H31N7 |
| Cas No. | 1359415-02-3 |
| Relative Density. | 1.28 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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