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Furaprofen

Name: Furaprofen
Brand: TargetMol
SKU: T16715
Price: 289 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T16715Cas No. 67700-30-5

Alias R-803, R803, R 803

Furaprofen is an orally available, selective and potent HCV inhibitor with anti-inflammatory activity, inhibits carrageenan-induced paw edema in rats and inhibits cotton pellet-induced granulomas in rats at higher doses.

Furaprofen

🥰Excellent

Purity: 99.52%

Catalog No. T16715Alias R-803, R803, R 803Cas No. 67700-30-5

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$289	In Stock	In Stock
5 mg	$689	In Stock	In Stock
10 mg	$987	In Stock	In Stock
25 mg	$1,520	In Stock	In Stock
50 mg	$1,980	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.52%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Furaprofen is an orally available, selective and potent HCV inhibitor with anti-inflammatory activity, inhibits carrageenan-induced paw edema in rats and inhibits cotton pellet-induced granulomas in rats at higher doses.
Targets&IC50	HCV 1a/1b:（EC50）~30 nM, HCV 2a:~1000 nM（EC50）
In vitro	The effectiveness of Furaprofen in inhibiting the replicon is verified through Western blotting and TaqMan RT-PCR, yielding IC50 values of approximately 37 nM and 54.67±4.11 nM, respectively. Furthermore, its antiviral potency, assessed via a reporter replicon assay conducted through multiple iterations, demonstrates a significant increase, standing at 29.88±8.05 nM—indicating an approximately threefold enhancement when compared to its precursor compound, R706. To evaluate Furaprofen's broader impact on cell proliferation, diverse primary and transformed human cell lines were subjected to escalating doses of the compound over a 48-hour period. The resultant effect on cell proliferation was quantified using an MTS-based cell viability assay, revealing the CC50 (the concentration required to diminish cell numbers by 50% in the absence of viral infection) of Furaprofen to vary between 2 μM and ≥10 μM, contingent upon the specific cell type and its proliferation state[1].
Synonyms	R-803, R803, R 803

Chemical Properties

Molecular Weight	266.29
Formula	C₁₇H₁₄O₃
Cas No.	67700-30-5
Smiles	CC(C(O)=O)c1cccc2c(coc12)-c1ccccc1
Relative Density.	1.23g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 200 mg/mL (751.06 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (18.78 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7553 mL	18.7765 mL	37.5530 mL	187.7652 mL
5 mM	0.7511 mL	3.7553 mL	7.5106 mL	37.5530 mL
10 mM	0.3755 mL	1.8777 mL	3.7553 mL	18.7765 mL
20 mM	0.1878 mL	0.9388 mL	1.8777 mL	9.3883 mL
50 mM	0.0751 mL	0.3755 mL	0.7511 mL	3.7553 mL
100 mM	0.0376 mL	0.1878 mL	0.3755 mL	1.8777 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc