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Fmoc-8-amino-3,6-dioxaoctanoic acid

🥰Excellent
Catalog No. T15304Cas No. 166108-71-0
Alias Fmoc-NH-PEG2-CH2COOH

Fmoc-8-amino-3,6-dioxaoctanoic acid (Fmoc-NH-PEG2-CH2COOH) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) and a PEG-based PROTAC linker for the synthesis of PROTACs.

Fmoc-8-amino-3,6-dioxaoctanoic acid

Fmoc-8-amino-3,6-dioxaoctanoic acid

🥰Excellent
Purity: 99.61%
Catalog No. T15304Alias Fmoc-NH-PEG2-CH2COOHCas No. 166108-71-0
Fmoc-8-amino-3,6-dioxaoctanoic acid (Fmoc-NH-PEG2-CH2COOH) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) and a PEG-based PROTAC linker for the synthesis of PROTACs.
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1 g$29In Stock
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Purity:99.61%
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Product Introduction

Bioactivity
Description
Fmoc-8-amino-3,6-dioxaoctanoic acid (Fmoc-NH-PEG2-CH2COOH) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) and a PEG-based PROTAC linker for the synthesis of PROTACs.
In vitro
Antibody-drug conjugates (ADCs) consist of an antibody linked to an ADC cytotoxin via an ADC linker.
SynonymsFmoc-NH-PEG2-CH2COOH
Chemical Properties
Molecular Weight385.41
FormulaC21H23NO6
Cas No.166108-71-0
SmilesOC(=O)COCCOCCNC(=O)OCC1c2ccccc2-c2ccccc12
Relative Density.1.265 g/cm3 (Predicted)
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 10 mM, Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.5946 mL12.9732 mL25.9464 mL129.7320 mL
5 mM0.5189 mL2.5946 mL5.1893 mL25.9464 mL
10 mM0.2595 mL1.2973 mL2.5946 mL12.9732 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

PROTACLinkerPROTAC LinkersPROTAC LinkerInhibitorinhibitFmoc-8-amino-3,6-dioxaoctanoic acidFmoc8amino3,6dioxaoctanoic acidFmoc 8 amino 3,6 dioxaoctanoic acidAntibody-drug conjugates linkersADCLinkerADC LinkersADC Linker
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