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A-770041

Name: A-770041
Brand: TargetMol
SKU: T14074
Price: 67 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14074Cas No. 869748-10-7

Alias A770041, A 770041

A-770041 is an orally active and selective Lck inhibitor that inhibits concanavalin A-stimulated IL-2 production in whole blood and prevents cardiac allograft rejection. A-770041 reduces pulmonary fibrosis by inhibiting TGF-β production in regulatory T cells.

A-770041

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Purity: 99.86%

Catalog No. T14074Alias A770041, A 770041Cas No. 869748-10-7

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$67	-	In Stock
5 mg	$112	-	In Stock
10 mg	$188	-	In Stock
25 mg	$427	-	In Stock
50 mg	$725	-	In Stock
100 mg	$1,130	-	In Stock
200 mg	$1,500	-	In Stock
1 mL x 10 mM (in DMSO)	$153	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.86%

Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description	A-770041 is an orally active and selective Lck inhibitor that inhibits concanavalin A-stimulated IL-2 production in whole blood and prevents cardiac allograft rejection. A-770041 reduces pulmonary fibrosis by inhibiting TGF-β production in regulatory T cells.
Targets&IC50	Src:9.1 μM, Lck:0.147 μM, Fyn:44.1 μM, FGR:14.1 μM
In vitro	A-770041 selectively inhibited LCK with IC50=0.147 μM; A-770041 inhibited other SRC family kinases with SRC IC50=9.1 μM, FGR IC50=14.1 μM, and FYN IC50=44.1 μM. [1] A-770041 dose-dependently (0-30 μM; 2 h) inhibited anti-CD3-induced IL-2 production with an EC50 = 80 nM. [1]
In vivo	Recipient animals were treated with vehicle control or 2.5 to 20 mg/kg/day of A-770041 in equally. Animals were treated for 14 days, and graft viability was assessed by abdominal palpation each day. A-770041 dosed at 2.5 mg/kg/day did not lengthen graft survival time. There was a dose-dependent increase in survival with doses of 5 and 10 mg/kg/day. At doses of 10 and 20 mg/kg/day of A-770041, 100% of transplanted grafts were still beating at 14 days. [1]
Synonyms	A770041, A 770041

Chemical Properties

Molecular Weight	621.73
Formula	C₃₄H₃₉N₉O₃
Cas No.	869748-10-7
Smiles	NC1=C2C(=NN(C2=NC=N1)[C@H]3CC[C@@H](CC3)N4CCN(C(C)=O)CC4)C5=CC(OC)=C(NC(=O)C6=CC=7C(N6C)=CC=CC7)C=C5
Relative Density.	1.42 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 20 mg/mL (32.17 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6084 mL	8.0421 mL	16.0842 mL	80.4208 mL
5 mM	0.3217 mL	1.6084 mL	3.2168 mL	16.0842 mL
10 mM	0.1608 mL	0.8042 mL	1.6084 mL	8.0421 mL
20 mM	0.0804 mL	0.4021 mL	0.8042 mL	4.0210 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc