Shopping Cart
- Remove All
Your shopping cart is currently empty
Ancriviroc
🥰Excellent
Catalog No. T30047Cas No. 370893-06-4
Alias Schering C, SCH-351125, CHEMBL336672, AC1NUILE, [3H]ancriviroc
Ancriviroc (SCH-351125) is an oxime-piperidine compound with strong antiretroviral activity and an orally bioavailable small molecule chemokine receptor CCR5 antagonist (Kd value 9.27nM) that enters HIV-1 through the CCR5 co-receptor and is used to study HIV-1.
Ancriviroc
🥰Excellent
Purity: 99.89%
Catalog No. T30047Alias Schering C, SCH-351125, CHEMBL336672, AC1NUILE, [3H]ancrivirocCas No. 370893-06-4
Ancriviroc (SCH-351125) is an oxime-piperidine compound with strong antiretroviral activity and an orally bioavailable small molecule chemokine receptor CCR5 antagonist (Kd value 9.27nM) that enters HIV-1 through the CCR5 co-receptor and is used to study HIV-1.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $195 | In Stock | |
| 5 mg | $483 | In Stock | |
| 10 mg | $692 | In Stock | |
| 25 mg | $1,080 | In Stock | |
| 50 mg | $1,490 | In Stock | |
| 100 mg | $1,970 | In Stock |
Add to Cart
Add to Quotation
Bulk & Custom
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
Questions
View MoreBatch Information
Select Batch
Purity:99.89%
Contact us for more batch information
Product Introduction
Bioactivity
Chemical Properties
| Description | Ancriviroc (SCH-351125) is an oxime-piperidine compound with strong antiretroviral activity and an orally bioavailable small molecule chemokine receptor CCR5 antagonist (Kd value 9.27nM) that enters HIV-1 through the CCR5 co-receptor and is used to study HIV-1. |
| In vitro | METHODS: Chinese hamster ovary (CHO) cell membranes expressing human CCR5 were incubated with Ancriviroc (SCH-351125) (10-0.3 nM), and Ki values were calculated using GRAPHPAD PRISM software based on experimentally determined IC50 and KD values. RESULTS Ancriviroc (SCH-351125) inhibited the binding of RANTES to CHO cell membranes expressing human CCR5 in a dose-dependent manner with a Ki value of 2.9 nM; Ancriviroc (SCH-351125) bound to CCR5 with high affinity with a KD of 9.27 nM. [1] |
| In vivo | METHODS: In a SCID-mouse model treated with (SCH-351125) (30 mg/kg, orally, daily), HLA-ABC levels on implanted cells from treated and untreated mice were measured by FACS analysis using mAb W6/32. RESULTS SCH-C had potent and dose-dependent antiviral activity in the SCID-mouse model; MHC class I expression on implanted cells from (SCH-351125)-treated mice was reduced in a dose-dependent manner, further confirming the inhibition of viral replication by SCH-C. [1] |
| Synonyms | Schering C, SCH-351125, CHEMBL336672, AC1NUILE, [3H]ancriviroc |
| Molecular Weight | 557.52 |
| Formula | C28H37BrN4O3 |
| Cas No. | 370893-06-4 |
| Smiles | C(=N/OCC)(\C1CCN(CC1)C2(C)CCN(C(=O)C3=C(C)N(=O)=CC=C3C)CC2)/C4=CC=C(Br)C=C4 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (89.68 mM), Sonication is recommended.  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
| |||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Sci Citations
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy Ancriviroc | purchase Ancriviroc | Ancriviroc cost | order Ancriviroc | Ancriviroc chemical structure | Ancriviroc in vivo | Ancriviroc in vitro | Ancriviroc formula | Ancriviroc molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2025 TargetMol Chemicals Inc. All Rights Reserved.