Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MS15 TFA is a potent, selective AKT PROTAC degrader, effectively inhibiting AKT1, AKT2, and AKT3 with IC50 values of 798 nM, 90 nM, and 544 nM, respectively [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | Inquiry | Inquiry | |
50 mg | Inquiry | Inquiry |
Description | MS15 TFA is a potent, selective AKT PROTAC degrader, effectively inhibiting AKT1, AKT2, and AKT3 with IC50 values of 798 nM, 90 nM, and 544 nM, respectively [1]. |
In vitro | MS15 (0-10 μM, 24 hours) TFA effectively induces AKT degradation in SW620 cells and MS21 resistant cells harboring KRAS/BRAF mutations [1]. Furthermore, MS15 (0-10 μM, 5 days) TFA suppresses the proliferation of KRAS mutant SW620 cells [1]. In a time- and UPS-dependent manner, MS15 (1 μM, 1-24 hours) TFA mediates AKT degradation [1]. |
In vivo | MS15, administered intraperitoneally at a dose of 75 mg/kg in a single injection, exhibits bioavailability [1] in mice. |
Molecular Weight | 1228.47 |
Formula | C66H80F3N11O7S |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
MS15 TFA PROTAC PROTACs inhibitor inhibit