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Anti-Phospho-PTEN (Ser380) Antibody (6S492)
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Catalog No. TMAC-03255
Alias TEP1, PTEN1, PTEN (p-Ser380), PTEN (p-S380), p-PTEN (Ser380), p-PTEN (S380), Phospho-PTEN (S380), Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, Phosphatase and tensin like protein, Phosphatase and tensin homolog, Mutated in multiple advanced cancers 1, MMAC1 phosphatase and tensin homolog deleted on chromosome 10, MMAC1, MHAM, MGC11227, GLM2, DEC, BZS, 10q23del
Anti-Phospho-PTEN (Ser380) Antibody (6S492) is a Rabbit antibody targeting Phospho-PTEN (Ser380). Anti-Phospho-PTEN (Ser380) Antibody (6S492) can be used in ICC,WB.
Anti-Phospho-PTEN (Ser380) Antibody (6S492)
Anti-Phospho-PTEN (Ser380) Antibody (6S492)
😃Good
Catalog No. TMAC-03255Alias TEP1, PTEN1, PTEN (p-Ser380), PTEN (p-S380), p-PTEN (Ser380), p-PTEN (S380), Phospho-PTEN (S380), Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, Phosphatase and tensin like protein, Phosphatase and tensin homolog, Mutated in multiple advanced cancers 1, MMAC1 phosphatase and tensin homolog deleted on chromosome 10, MMAC1, MHAM, MGC11227, GLM2, DEC, BZS, 10q23del
Anti-Phospho-PTEN (Ser380) Antibody (6S492) is a Rabbit antibody targeting Phospho-PTEN (Ser380). Anti-Phospho-PTEN (Ser380) Antibody (6S492) can be used in ICC,WB.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $296 | 7-10 days | |
| 100 μL | $497 | 7-10 days |
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| Description | Anti-Phospho-PTEN (Ser380) Antibody (6S492) is a Rabbit antibody targeting Phospho-PTEN (Ser380). Anti-Phospho-PTEN (Ser380) Antibody (6S492) can be used in ICC,WB. |
| Synonyms | TEP1, PTEN1, PTEN (p-Ser380), PTEN (p-S380), p-PTEN (Ser380), p-PTEN (S380), Phospho-PTEN (S380), Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, Phosphatase and tensin like protein, Phosphatase and tensin homolog, Mutated in multiple advanced cancers 1, MMAC1 phosphatase and tensin homolog deleted on chromosome 10, MMAC1, MHAM, MGC11227, GLM2, DEC, BZS, 10q23del |
| Ig Type | IgG |
| Clone | 6S492 |
| Reactivity | Human,Mouse,Rat |
| Verified Activity | 1. Western blot analysis of Phospho-PTEN (S380) on different lysates using anti-Phospho-PTEN (S380) antibody at 1/1,000 dilution. Positive control: Lane 1: Human placenta, Lane 2: Human lung. 2. ICC staining Phospho-PTEN (S380) in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 3. ICC staining Phospho-PTEN (S380) in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 4. ICC staining Phospho-PTEN (S380) in SW480 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. |
| Application | |
| Recommended Dose | WB: 1:1000-2000; ICC: 1:100-500 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | Recombinant Antibody |
| Purification | ProA affinity purified |
| Appearance | Liquid |
| Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Research Background | As human tumors progress to advanced stages, one genetic alteration that occurs at high frequency is a loss of heterozygosity (LOH) at chromosome 10q23. Mapping of homozygous deletions on this chromosome led to the isolation of the PTEN gene, also designated MMAC1 (for mutated in multiple advanced cancers) and TEP1. This candidate tumor suppressor gene exhibits a high frequency of mutations in human glioblastomas and is also mutated in other cancers, including sporadic brain, breast, kidney and prostate cancers. PTEN has been associated with Cowden disease, an autosomal dominant cancer predisposition syndrome. The PTEN gene product is a putative protein tyrosine phosphatase that is localized to the cytoplasm and shares extensive homology with the cytoskeletal proteins tensin and auxilin. Gene transfer studies have indicated that the phosphatase domain of PTEN is essential for growth suppression of glioma cells. |
| Conjucates | Unconjugated |
| Others Formats | Phospho |
| Immunogen | A synthesized phosphopeptide: human PTEN around the phosphorylation site of Ser380 |
| Antigen Species | human |
| Uniprot ID |
| Molecular Weight | Theoretical: 55 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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