Shopping Cart
Remove All
Your shopping cart is currently empty
BRD4/NAMPT-IN-1
Copy Product Info
😃Good
Catalog No. T210348Cas No. 3049218-28-9
BRD4/NAMPT-IN-1 (Compound A2) exhibits strong inhibitory effects on NAMPT and BRD4, with IC50 values of 35 nM (NAMPT) and 58 nM (BRD4). This compound significantly suppresses the growth and migration of liver cancer cells while promoting apoptosis. Additionally, BRD4/NAMPT-IN-1 demonstrates potent anticancer activity in HCCLM3 xenograft mouse models without noticeable toxicity.
BRD4/NAMPT-IN-1
Copy Product Info😃Good
Catalog No. T210348Cas No. 3049218-28-9
BRD4/NAMPT-IN-1 (Compound A2) exhibits strong inhibitory effects on NAMPT and BRD4, with IC50 values of 35 nM (NAMPT) and 58 nM (BRD4). This compound significantly suppresses the growth and migration of liver cancer cells while promoting apoptosis. Additionally, BRD4/NAMPT-IN-1 demonstrates potent anticancer activity in HCCLM3 xenograft mouse models without noticeable toxicity.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
Add to Quotation
In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Resource Download
Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | BRD4/NAMPT-IN-1 (Compound A2) exhibits strong inhibitory effects on NAMPT and BRD4, with IC50 values of 35 nM (NAMPT) and 58 nM (BRD4). This compound significantly suppresses the growth and migration of liver cancer cells while promoting apoptosis. Additionally, BRD4/NAMPT-IN-1 demonstrates potent anticancer activity in HCCLM3 xenograft mouse models without noticeable toxicity. |
| Targets&IC50 | BRD4 BD1:12 nM, BRD4 BD1/2:58 nM, BRD4 BD2:41 nM |
| In vitro | BRD4/NAMPT-IN-1 exhibits IC 50 values of 12 nM for BRD4(BD1) and 41 nM for BRD4(BD2) against other members of the BET family. It inhibits cancer cell proliferation with IC 50 values of 2.37 μM in Hep3B, 6.49 μM in Huh7, 5.44 μM in HCCLM3, and 9.51 μM in LX-2 cells. Treating Hep3B cells with BRD4/NAMPT-IN-1 (1-10 μM; 72 h) suppresses the expression of BRD4-upregulated oncogenes, reduces NAPRT and NAMPT levels, significantly increases cell arrest in the G0/G1 phase, induces apoptosis in a dose-dependent manner, and inhibits cell migration ability. Additionally, BRD4/NAMPT-IN-1 (1-10 μM; 72 h) reduces NAD+ concentration in Hep3B and HCCLM3 cells in a dose-dependent fashion. |
| In vivo | Administered intraperitoneally (i.p.) at 40 mg/kg/day and 80 mg/kg/day for 27 consecutive days, BRD4/NAMPT-IN-1 shows a dose-dependent tumor suppressive effect in HCCLM3 xenograft nude mice. |
| Molecular Weight | 588.12 |
| Formula | C30H30ClN7O2S |
| Cas No. | 3049218-28-9 |
| Smiles | CC=1C2=C(N3C([C@H](CC(NCCCNC(/C=C/C=4C=CC=NC4)=O)=O)N=C2C5=CC=C(Cl)C=C5)=NN=C3C)SC1C |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy BRD4/NAMPT-IN-1 | purchase BRD4/NAMPT-IN-1 | BRD4/NAMPT-IN-1 cost | order BRD4/NAMPT-IN-1 | BRD4/NAMPT-IN-1 chemical structure | BRD4/NAMPT-IN-1 in vivo | BRD4/NAMPT-IN-1 in vitro | BRD4/NAMPT-IN-1 formula | BRD4/NAMPT-IN-1 molecular weight
Generate Quote
Catalog No.: Cas No.:
Add
| Size | Quantity | Unit Price | Amount | Operation |
|---|
Generate Quote
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.