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AZD5904

Name: AZD5904
Brand: TargetMol
SKU: T14379
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14379Cas No. 618913-30-7

AZD5904 is a potent and irreversible inhibitor of human Myeloperoxidase (MPO, IC50: 140 nM) which has similar potency in mouse and rat.

AZD5904

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Purity: 99.89%

Catalog No. T14379Cas No. 618913-30-7

AZD5904 is a potent and irreversible inhibitor of human Myeloperoxidase (MPO, IC50: 140 nM) which has similar potency in mouse and rat.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$30	In Stock	In Stock
5 mg	$66	In Stock	In Stock
10 mg	$123	In Stock	In Stock
25 mg	$289	In Stock	In Stock
50 mg	$513	In Stock	In Stock
100 mg	$787	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$73	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.89%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	AZD5904 is a potent and irreversible inhibitor of human Myeloperoxidase (MPO, IC50: 140 nM) which has similar potency in mouse and rat.
Targets&IC50	MPO (human):140 nM
In vitro	In isolated human neutrophils, 1 μM AZD5904 inhibits PMA stimulated HOCl by >90%[1]. It is 10 to 19-fold selective compare to the closely related lactoperoxidase and thyroid peroxidase. For a broad panel of other enzymes, ion channels, and receptors, is higher than >70-fold.

Chemical Properties

Molecular Weight	252.29
Formula	C₁₀H₁₂N₄O₂S
Cas No.	618913-30-7
Smiles	O=c1[nH]c(=S)n(C[C@H]2CCCO2)c2[nH]cnc12
Relative Density.	1.54 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 65 mg/mL (257.64 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Saline: 2.5 mg/mL (9.91 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9637 mL	19.8185 mL	39.6369 mL	198.1846 mL
5 mM	0.7927 mL	3.9637 mL	7.9274 mL	39.6369 mL
10 mM	0.3964 mL	1.9818 mL	3.9637 mL	19.8185 mL
20 mM	0.1982 mL	0.9909 mL	1.9818 mL	9.9092 mL
50 mM	0.0793 mL	0.3964 mL	0.7927 mL	3.9637 mL
100 mM	0.0396 mL	0.1982 mL	0.3964 mL	1.9818 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc