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BIIB129

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Catalog No. T88336Cas No. 2770960-52-4
Alias BIIB 129

BIIB129 is a selective and brain-penetrant BTK covalent inhibitor used to study B-cell proliferation-related diseases.

BIIB129

BIIB129

😃Good
Purity: 98.56%
Catalog No. T88336Alias BIIB 129Cas No. 2770960-52-4
BIIB129 is a selective and brain-penetrant BTK covalent inhibitor used to study B-cell proliferation-related diseases.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$64In StockIn Stock
5 mg$156In StockIn Stock
10 mg$222In StockIn Stock
25 mg$378In StockIn Stock
50 mg$569In StockIn Stock
100 mg$795-In Stock
200 mg$1,070-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:98.56%
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Product Introduction

Bioactivity
Description
BIIB129 is a selective and brain-penetrant BTK covalent inhibitor used to study B-cell proliferation-related diseases.
In vitro
BIIB129 inhibited the activation and translocation of NF-κB to the nucleus in TMD8 cells, IC50 = 1.9 nM; In human peripheral blood mononuclear cells (PBMCs), IC50 = 13 nM inhibits anti-IGD-induced B-cell activation.
In vivo
A mouse model of oral BIIB129 (BID 0.1, 0.3, 1, 3.2, 10, and 31.7 mg/kg, respectively) showed a dose-dependent reduction in Ki67+ microglia proliferation and EC50 = 1.5 mg/kg.
SynonymsBIIB 129
Chemical Properties
Molecular Weight366.42
FormulaC19H22N6O2
Cas No.2770960-52-4
SmilesO(C=1C=2N(C=C(N1)C3=CN(C)N=C3)N=CC2)[C@@]4(C)C[C@@H](N(C(C=C)=O)C)C4
ColorYellow
AppearanceSolid
Storage & Solubility Information
Storagekeep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 80 mg/mL (218.33 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (9.01 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.7291 mL13.6455 mL27.2911 mL136.4554 mL
5 mM0.5458 mL2.7291 mL5.4582 mL27.2911 mL
10 mM0.2729 mL1.3646 mL2.7291 mL13.6455 mL
20 mM0.1365 mL0.6823 mL1.3646 mL6.8228 mL
50 mM0.0546 mL0.2729 mL0.5458 mL2.7291 mL
100 mM0.0273 mL0.1365 mL0.2729 mL1.3646 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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