Contact UsQuotation
Shopping Cart
Remove All
  • TargetMol
    Your shopping cart is currently empty
Proceed to checkoutContinue shopping
TOPBioactivityChemical infoStorage&SolubilityCalculator

Lotamilast

🥰Excellent
Catalog No. T3987Cas No. 947620-48-6
Alias RVT-501, E6005

Lotamilast (RVT-501) is a phosphodiesterase 4 (PDE-4) inhibitor (IC50: 2.8 nM) potentially for the treatment of atopic dermatitis.

Lotamilast

Lotamilast

🥰Excellent
Purity: 99.29%
Catalog No. T3987Alias RVT-501, E6005Cas No. 947620-48-6
Lotamilast (RVT-501) is a phosphodiesterase 4 (PDE-4) inhibitor (IC50: 2.8 nM) potentially for the treatment of atopic dermatitis.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
2 mg$33In StockIn Stock
5 mg$52In StockIn Stock
10 mg$79In StockIn Stock
25 mg$158In StockIn Stock
50 mg$239In StockIn Stock
100 mg$363In StockIn Stock
1 mL x 10 mM (in DMSO)$54In StockIn Stock
Add to Cart
Add to Quotation
In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Questions
TargetMol
View More

Batch Information

Select Batch
Purity:99.29%
Contact us for more batch information

Resource Download

COA

Product Introduction

Bioactivity
Description
Lotamilast (RVT-501) is a phosphodiesterase 4 (PDE-4) inhibitor (IC50: 2.8 nM) potentially for the treatment of atopic dermatitis.
Targets&IC50
PDE4:2.8 nM
SynonymsRVT-501, E6005
Chemical Properties
Molecular Weight472.49
FormulaC26H24N4O5
Cas No.947620-48-6
SmilesCNc1nc(-c2cccc(NC(=O)c3ccc(cc3)C(=O)OC)c2)c2cc(OC)c(OC)cc2n1
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 50 mg/mL (105.82 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1164 mL10.5822 mL21.1645 mL105.8223 mL
5 mM0.4233 mL2.1164 mL4.2329 mL21.1645 mL
10 mM0.2116 mL1.0582 mL2.1164 mL10.5822 mL
20 mM0.1058 mL0.5291 mL1.0582 mL5.2911 mL
50 mM0.0423 mL0.2116 mL0.4233 mL2.1164 mL
100 mM0.0212 mL0.1058 mL0.2116 mL1.0582 mL

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

RVT501RVT 501Phosphodiesterase (PDE)phosphodiesterasePDE4LotamilastInhibitorinhibitE-6005E 6005
Related Tags: buy Lotamilast | purchase Lotamilast | Lotamilast cost | order Lotamilast | Lotamilast chemical structure | Lotamilast formula | Lotamilast molecular weight
TargetMol | Logo

Copyright © 2015-2025 TargetMol Chemicals Inc. All Rights Reserved.