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AAK1 (AP2-associated kinase 1) is a serine/threonine kinase belonging to the Numb-associated kinase (NAK) family, primarily involved in clathrin-mediated endocytosis. It regulates the efficiency of receptor binding to endocytic vesicles by phosphorylating the μ2 subunit of the AP2 complex, thereby influencing the endocytosis and recycling of various membrane proteins such as transporters and receptors. AAK1 is particularly crucial in the recycling of synaptic vesicles within neurons, being closely associated with neurotransmitter release and synaptic plasticity. Furthermore, AAK1 has been identified as participating in viral entry and signal transduction processes, positioning it as a potential therapeutic target for antiviral agents and neuropsychiatric disorder drug development.
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