Shopping Cart

Your shopping cart is currently empty

Adiphenine hydrochloride

Name: Adiphenine hydrochloride
Brand: TargetMol
SKU: T0072
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T0072Cas No. 50-42-0

Alias Spasnil, Sentiv, Patrovina, Adiphenine HCl

Adiphenine hydrochloride (Patrovina), a nicotinic receptor inhibitor, can be used as an antispasmodic drug.

Adiphenine hydrochloride

Copy Product Info

😃Good

Purity: 99.53%

Catalog No. T0072Alias Spasnil, Sentiv, Patrovina, Adiphenine HClCas No. 50-42-0

Adiphenine hydrochloride (Patrovina), a nicotinic receptor inhibitor, can be used as an antispasmodic drug.

Pack Size	Price	USA Warehouse	Global Warehouse
200 mg	$30	In Stock	In Stock
500 mg	$60	In Stock	In Stock
1 g	$87	-	In Stock
5 g	$213	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.53%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Adiphenine hydrochloride AI Summary

Adiphenine hydrochloride exhibits antispasmodic activity on guinea pig ileum and rat ileum by inhibiting muscle contractions induced by metacholine, with ID50 values of 7.4E-7 M and 3.55E-8 M, respectively. It has an affinity for the Muscarinic acetylcholine receptor (Kd = 35.48 nM) and shows similar potency to adiphenine. Adiphenine hydrochloride also modulates various bioactivities: it enhances SMN2 splice variant expression (potency 562.3 nM), inhibits ALDH1A1 (potencies of 11220.2 nM and 25118.9 nM), modulates IMPase (potency 316.2 nM), activates Cytochrome P450 3A4 (potency 6309.6 nM), and inhibits BAZ2B (potency 89125.1 nM) as well as 15-human lipoxygenase 2 (potency 15848.9 nM). It induces DNA re-replication in MCF 10a cells (potency 18356.4 nM) and inhibits human TDP1 in various conditions (potencies 14963.1 nM to 29092.9 nM). Additionally, it demonstrates inhibitory activity in assays related to TDP-43, APE1, and Ebola Virus entry. It significantly inhibits sodium fluorescein uptake in OATP1B1-transfected (59.48%) and OATP1B3-transfected (95.82%) CHO cells at 10 µM. With limited efficacy in inhibiting the cell viability of SARS-CoV-2 infected Vero E6 cells (inhibition index 0.1368), Adiphenine hydrochloride also shows antiviral activity against SARS-CoV-2, inhibiting virus-induced cytotoxicity of Caco-2 cells (0.38% inhibition at 10 µM) and VERO-6 cells (0.03% inhibition at 10 µM, 48 hours post-exposure to 0.01 MOI). Additionally, it inhibits SARS-CoV-2 3CL-Pro protease by 8.244% at 20 µM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Adiphenine hydrochloride (Patrovina), a nicotinic receptor inhibitor, can be used as an antispasmodic drug.
Targets&IC50	α1 nAChR:1.9 µM (IC50), α4β4 nAChR:6.3 µM (IC50), α4β2 nAChR:3.7 µM (IC50), α3β4 nAChR:1.8 µM (IC50)
Synonyms	Spasnil, Sentiv, Patrovina, Adiphenine HCl

Chemical Properties

Molecular Weight	347.88
Formula	C₂₀H₂₅NO₂·HCl
Cas No.	50-42-0
Smiles	O=C(OCCN(CC)CC)C(C1=CC=CC=C1)C2=CC=CC=C2.[H]Cl
Relative Density.	1.0555 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (143.73 mM), Sonication is recommended.

H2O: 64 mg/mL (183.97 mM), Sonication is recommended.

Ethanol: 15 mg/mL (43.12 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2.5 mg/mL (7.19 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.8746 mL	14.3728 mL	28.7455 mL	143.7277 mL
5 mM	0.5749 mL	2.8746 mL	5.7491 mL	28.7455 mL
10 mM	0.2875 mL	1.4373 mL	2.8746 mL	14.3728 mL
20 mM	0.1437 mL	0.7186 mL	1.4373 mL	7.1864 mL

DMSO/H2O

	1mg	5mg	10mg	50mg
50 mM	0.0575 mL	0.2875 mL	0.5749 mL	2.8746 mL
100 mM	0.0287 mL	0.1437 mL	0.2875 mL	1.4373 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc