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Diatrizoic Acid

Name: Diatrizoic Acid
Brand: TargetMol
SKU: T1395
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1395Cas No. 117-96-4

Alias Diatrizoate, Amidotrizoic acid

Diatrizoic Acid (Amidotrizoic acid) is an organic, iodinated radiopaque X-ray contrast medium used in diagnostic radiography.

Diatrizoic Acid

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Purity: 97.34%

Catalog No. T1395Alias Diatrizoate, Amidotrizoic acidCas No. 117-96-4

Diatrizoic Acid (Amidotrizoic acid) is an organic, iodinated radiopaque X-ray contrast medium used in diagnostic radiography.

Pack Size	Price	USA Warehouse	Global Warehouse
1 g	$34	In Stock	In Stock
5 g	$77	-	In Stock
10 g	$113	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:97.34%

Appearance:Solid

Color:White

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COA LCMS

Product Introduction

Bioactivity

Description	Diatrizoic Acid (Amidotrizoic acid) is an organic, iodinated radiopaque X-ray contrast medium used in diagnostic radiography.
Kinase Assay	Radiochemical enzyme assays for COX-1 and COX-2: 10 μL of purified COX-1 (0.7-0.8 μg) or COX-2 (3.0 units, 0.3μg) is activated with 50 μL of cofactor solution [l-epinephrine (1.3 mg/mL), reduced glutathione (0.3 mg/mL), and hematin (1.3 mg/mL) in oxygen-free Tris-HCl buffer (pH 8.0)]. The enzyme solution (60 μL) is added to Ibuprofen solutions or DMSO (20 μL) after [14C]arachidonic acid is added in 0.2 mL eight-strip test tubes and preincubated 10 minutes on ice. Samples are incubated for 15 minutes at 37 °C, after which the reaction is terminated by addition of 10 μL of 2 M HCl and 5 μL of carrier solution (PGE2 and PGF2α, 0.2 μg/mL of each in EtOH). The unmetabolized arachidonic acid is separated from the prostaglandin products by column chromatography and eluted with n-hexane-dioxane-glacial acetic acid (70:30:1). The prostaglandin products are then eluted with EtOAc-MeOH (85:15), and the samples are counted in a Packard scintillation spectrometer. IC50 values are obtained by linear regression analysis.
Synonyms	Diatrizoate, Amidotrizoic acid

Chemical Properties

Molecular Weight	613.91
Formula	C₁₁H₉I₃N₂O₄
Cas No.	117-96-4
Smiles	N(C(C)=O)C1=C(I)C(C(O)=O)=C(I)C(NC(C)=O)=C1I
Relative Density.	2.619 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (89.59 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.26 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6289 mL	8.1445 mL	16.2890 mL	81.4452 mL
5 mM	0.3258 mL	1.6289 mL	3.2578 mL	16.2890 mL
10 mM	0.1629 mL	0.8145 mL	1.6289 mL	8.1445 mL
20 mM	0.0814 mL	0.4072 mL	0.8145 mL	4.0723 mL
50 mM	0.0326 mL	0.1629 mL	0.3258 mL	1.6289 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc