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1-(2-Pyridyl)piperazine

Name: 1-(2-Pyridyl)piperazine
Brand: TargetMol
SKU: T5105
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5105Cas No. 34803-66-2

Alias NSC13778

1-(2-Pyridyl)piperazine (NSC-13778) is a selective α2-adrenoceptor antagonists. 1-(2-Pyridyl)piperazine shows sympatholytic activity. 1-(2-Pyridyl)piperazine is also a metabolite of Azaperone.

1-(2-Pyridyl)piperazine

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Purity: 98.92%

Catalog No. T5105Alias NSC13778Cas No. 34803-66-2

1-(2-Pyridyl)piperazine (NSC-13778) is a selective α2-adrenoceptor antagonists. 1-(2-Pyridyl)piperazine shows sympatholytic activity. 1-(2-Pyridyl)piperazine is also a metabolite of Azaperone.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 g	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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Purity:98.92%

Appearance:Liquid

Color:Transparent

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Product Introduction

1-(2-Pyridyl)piperazine AI Summary

1-(2-Pyridyl)piperazine exhibits potent bioactivities involving adrenergic receptors, showing a high affinity for alpha-2 adrenergic receptors with Ki values of 37.0 nM and 398.11 nM in various assays. It has a lower affinity for alpha-1 adrenergic receptors, with Ki values of 2400.0 nM and 1995.26 nM. The compound shows significant selectivity for alpha-2 over alpha-1 adrenergic receptors, as indicated by selectivity ratios of 65.0 and 5.0. Furthermore, 1-(2-Pyridyl)piperazine demonstrates antagonistic activity towards both alpha-2 and alpha-1 adrenergic receptors in rat vas deferens and central alpha-2 adrenergic receptors in anesthetized rats, particularly by reversing clonidine-induced mydriasis. It also inhibits PLD1 in human Calu1 cells with an IC50 of 3600.0 nM and inhibits recombinant N-terminal truncated human cytosolic 5'-nucleotidase-2 with an inhibition rate of 0.5% at a concentration of 1 mM. The pKa (acid-base dissociation constant) for 1-(2-Pyridyl)piperazine is 8.9, as reported in a study by Morgenthaler in ChemMedChem 2007..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	1-(2-Pyridyl)piperazine (NSC-13778) is a selective α2-adrenoceptor antagonists. 1-(2-Pyridyl)piperazine shows sympatholytic activity. 1-(2-Pyridyl)piperazine is also a metabolite of Azaperone.
Synonyms	NSC13778

Chemical Properties

Molecular Weight	163.22
Formula	C₉H₁₃N₃
Cas No.	34803-66-2
Smiles	C1CN(CCN1)C1=NC=CC=C1
Relative Density.	1.072

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 100 mg/mL (612.67 mM), Sonication is recommended.

DMSO: Soluble

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	6.1267 mL	30.6335 mL	61.2670 mL	306.3350 mL
5 mM	1.2253 mL	6.1267 mL	12.2534 mL	61.2670 mL
10 mM	0.6127 mL	3.0634 mL	6.1267 mL	30.6335 mL
20 mM	0.3063 mL	1.5317 mL	3.0634 mL	15.3168 mL
50 mM	0.1225 mL	0.6127 mL	1.2253 mL	6.1267 mL
100 mM	0.0613 mL	0.3063 mL	0.6127 mL	3.0634 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc