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Anti-USP5 Antibody (5C807)

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Catalog No. TMAB-14027

Anti-USP5 Antibody (5C807) is a Mouse antibody targeting USP5. Anti-USP5 Antibody (5C807) can be used in WB.

Anti-USP5 Antibody (5C807)

Anti-USP5 Antibody (5C807)

😃Good
Catalog No. TMAB-14027
Anti-USP5 Antibody (5C807) is a Mouse antibody targeting USP5. Anti-USP5 Antibody (5C807) can be used in WB.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 μL$2207-10 days7-10 days
100 μL$3727-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-USP5 Antibody (5C807) is a Mouse antibody targeting USP5. Anti-USP5 Antibody (5C807) can be used in WB.
Ig Type
IgG1, k
Clone
5C807
Reactivity
Human,Mouse,Rat
Application
Recommended Dose
WB: 1:500-2000
Antibody Type
Monoclonal
Host SpeciesMouse
ConstructionHybridoma Monoclonal Antibody
PurificationProtein G purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundProfound changes in patterns of gene expression can result from relatively small changes in the concentrations of sequence specific transcription factors. Ubiquitin (see MIM 191339)-dependent proteolysis is a complex pathway of protein metabolism implicated in such diverse cellular functions as maintenance of chromatin structure, receptor function, and degradation of abnormal proteins. A late step of the process involves disassembly of the polyubiquitin chains on degraded proteins into ubiquitin monomers. USP5 disassembles branched polyubiquitin chains by a sequential exo mechanism, starting at the proximal end of the chain (Wilkinson et al., 1995 [PubMed 7578059]).[supplied by OMIM, Mar 2010]
Antigen Details
Immunogen
Recombinant Protein: human USP5
Antigen Species
Human
Gene Name
USP5
Gene ID
Protein Name
Ubiquitin specific peptidase 5
Uniprot ID
Function
Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys-63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition.
Chemical Properties
Molecular WeightTheoretical: 96 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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