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Anti-USP5 Antibody (5C807)
Catalog No. TMAB-14027 Copy Product Info
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Anti-USP5 Antibody (5C807) is a Mouse antibody targeting USP5. Anti-USP5 Antibody (5C807) can be used in WB.
Anti-USP5 Antibody (5C807)
Copy Product Info🥰Excellent
Catalog No. TMAB-14027
Anti-USP5 Antibody (5C807) is a Mouse antibody targeting USP5. Anti-USP5 Antibody (5C807) can be used in WB.
Anti-USP5 Antibody
(5C807)
(5C807)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $220 | 7-10 days | 7-10 days | |
| 100 μL | $372 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-USP5 Antibody (5C807) is a Mouse antibody targeting USP5. Anti-USP5 Antibody (5C807) can be used in WB. |
| Ig Type | IgG1, k |
| Clone | 5C807 |
| Reactivity | Human,Mouse,Rat |
| Verified Activity | Sample: Lane 1: Mouse Liver tissue lysates Lane 2: Mouse Kidney tissue lysates Lane 3: Mouse Heart tissue lysates Lane 4: Mouse Testis tissue lysates Lane 5: Rat Cerebrum tissue lysates Lane 6: Rat Testis tissue lysates Lane 7: Human U251 cell lysates Lane 8: Human HeLa cell lysates Lane 9: Human Jurkat cell lysates Lane 10: Human MCF-7 cell lysates Primary: Anti-USP5 (TMAB-14027) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Mouse IgG at 1/20000 dilution Predicted band size: 96 kDa Observed band size: 103 kDa |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Protein G purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | Profound changes in patterns of gene expression can result from relatively small changes in the concentrations of sequence specific transcription factors. Ubiquitin (see MIM 191339)-dependent proteolysis is a complex pathway of protein metabolism implicated in such diverse cellular functions as maintenance of chromatin structure, receptor function, and degradation of abnormal proteins. A late step of the process involves disassembly of the polyubiquitin chains on degraded proteins into ubiquitin monomers. USP5 disassembles branched polyubiquitin chains by a sequential exo mechanism, starting at the proximal end of the chain (Wilkinson et al., 1995 [PubMed 7578059]).[supplied by OMIM, Mar 2010] |
| Immunogen | Recombinant Protein: human USP5 |
| Antigen Species | Human |
| Gene Name | USP5 |
| Gene ID | |
| Protein Name | Ubiquitin specific peptidase 5 |
| Uniprot ID | |
| Function | Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys-63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition. |
| Molecular Weight | Theoretical: 96 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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