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AHR agonist 10
Catalog No. T213613 Copy Product Info
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AHR agonist 10 is a potent activator of the AHR pathway (EC50 = 2.01 nM). It enhances transcription of key downstream target genes of AHR, such as CYP1A1 and CYP1B1, while reducing the expression of CD36 and IL-18, and demonstrates low cytotoxicity in normal cells (> 40 μM). This compound inhibits the expression of CCL5, CCL20, IL-6, IL-8, S100A9, TLR4, TNF-α, and TNFR1, indicating its effective regulation of inflammatory responses via AHR-dependent signaling. AHR agonist 10 is applicable in psoriasis research [1].
AHR agonist 10
Copy Product Info🥰Excellent
Catalog No. T213613
AHR agonist 10 is a potent activator of the AHR pathway (EC50 = 2.01 nM). It enhances transcription of key downstream target genes of AHR, such as CYP1A1 and CYP1B1, while reducing the expression of CD36 and IL-18, and demonstrates low cytotoxicity in normal cells (> 40 μM). This compound inhibits the expression of CCL5, CCL20, IL-6, IL-8, S100A9, TLR4, TNF-α, and TNFR1, indicating its effective regulation of inflammatory responses via AHR-dependent signaling. AHR agonist 10 is applicable in psoriasis research [1].
AHR agonist 10
Cas No. 1191937-43-5
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
For research use only—not for human use. No sales to individuals. Use as intended only.
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Storage & Solubility Information
| Description | AHR agonist 10 is a potent activator of the AHR pathway (EC50 = 2.01 nM). It enhances transcription of key downstream target genes of AHR, such as CYP1A1 and CYP1B1, while reducing the expression of CD36 and IL-18, and demonstrates low cytotoxicity in normal cells (> 40 μM). This compound inhibits the expression of CCL5, CCL20, IL-6, IL-8, S100A9, TLR4, TNF-α, and TNFR1, indicating its effective regulation of inflammatory responses via AHR-dependent signaling. AHR agonist 10 is applicable in psoriasis research [1]. |
| In vitro | AHR agonist 10 (Compound B19) effectively enhances the expression levels of CYP1A1 and CYP1B1 in AHR knockdown HaCaT cells at concentrations of 10 μM and 20 μM over a period of 24 hours. At a concentration of 5 μM, AHR agonist 10 suppresses the mRNA expression of CYP1A1, CYP1B1, CCL5, CCL20, IL-6, IL-8, S100A9, TLR4, TNF-α, and TNFR1 in Lipopolysaccharides (LPS)-induced HaCaT cells. |
| In vivo | An AHR agonist at a concentration of 10 (1%, applied topically, once daily for 7 days) inhibited the onset and progression of psoriasis-like symptoms induced by Imiquimod on the dorsal area of mice, as evidenced by a reduction in erythema and scaling. |
| Molecular Weight | 284.36 |
| Formula | C18H20O3 |
| Cas No. | 1191937-43-5 |
| Smiles | C(C)(C)C1=C(O)C=C(/C=C/C2=CC=C(OC)C=C2)C=C1O |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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