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SX-517

Name: SX-517
Brand: TargetMol
SKU: T28893
Price: 149 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T28893Cas No. 1240494-13-6

Alias SX517, SX 517

SX-517 is a non-competitive dual antagonist of CXCR1/2, demonstrating anti-inflammatory effects in both PMN cells and mouse models. SX-517 inhibits CXCL-1-induced Ca²⁺ flux (IC₅₀ = 38 nM), antagonises CXCL-8-induced [(³⁵)S]GTPγS binding (IC₅₀ = 60 nM), and suppresses ERK1/2 phosphorylation.

SX-517

🥰Excellent

Catalog No. T28893Alias SX517, SX 517Cas No. 1240494-13-6

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$149	-	In Stock
5 mg	Preferential	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	SX-517 is a non-competitive dual antagonist of CXCR1/2, demonstrating anti-inflammatory effects in both PMN cells and mouse models. SX-517 inhibits CXCL-1-induced Ca²⁺ flux (IC₅₀ = 38 nM), antagonises CXCL-8-induced [(³⁵)S]GTPγS binding (IC₅₀ = 60 nM), and suppresses ERK1/2 phosphorylation.
In vitro	SX-517 (0.1 nM-0.1 mM; 60 minutes) inhibited 10 nM CXCL8-induced [35S]GTPγS binding with an IC50 of 60 nM [1]. SX-517 (10 μM; 60 minutes) suppressed the cell surface expression of CXCR2 receptors in HEK293 cells [1]. SX-517 (10 μM; 0-30 minutes) blocked CXCR2-mediated ERK1/2 phosphorylation in HEK293 cells [1].
In vivo	SX-517 (0.02 mg/kg and 0.2 mg/kg) was administered via single intravenous injection to male CD1 SWISS mice bearing utetheisa ornatrix air pouches on their backs. The results demonstrated a significant reduction in cell counts within the utetheisa ornatrix air pouches of the mice [1].
Synonyms	SX517, SX 517

Chemical Properties

Molecular Weight	382.22
Formula	C₁₉H₁₆BFN₂O₃S
Cas No.	1240494-13-6
Smiles	O=C(NC1=CC=C(F)C=C1)C2=CN=C(SCC=3C=CC=CC3B(O)O)C=C2
Relative Density.	1.39 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (209.3 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (8.63 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6163 mL	13.0815 mL	26.1629 mL	130.8147 mL
5 mM	0.5233 mL	2.6163 mL	5.2326 mL	26.1629 mL
10 mM	0.2616 mL	1.3081 mL	2.6163 mL	13.0815 mL
20 mM	0.1308 mL	0.6541 mL	1.3081 mL	6.5407 mL
50 mM	0.0523 mL	0.2616 mL	0.5233 mL	2.6163 mL
100 mM	0.0262 mL	0.1308 mL	0.2616 mL	1.3081 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc