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SX-517

Name: SX-517
Brand: TargetMol
SKU: T28893
Price: 149 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T28893Cas No. 1240494-13-6

Alias SX517, SX 517

SX-517 is a non-competitive dual antagonist of CXCR1/2, demonstrating anti-inflammatory effects in both PMN cells and mouse models. SX-517 inhibits CXCL-1-induced Ca²⁺ flux (IC₅₀ = 38 nM), antagonises CXCL-8-induced [(³⁵)S]GTPγS binding (IC₅₀ = 60 nM), and suppresses ERK1/2 phosphorylation.

SX-517

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Purity: 99.90%

Catalog No. T28893Alias SX517, SX 517Cas No. 1240494-13-6

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$149	-	In Stock
5 mg	Preferential	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.90%

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COA MS HNMR HPLC

Product Introduction

Bioactivity

Description	SX-517 is a non-competitive dual antagonist of CXCR1/2, demonstrating anti-inflammatory effects in both PMN cells and mouse models. SX-517 inhibits CXCL-1-induced Ca²⁺ flux (IC₅₀ = 38 nM), antagonises CXCL-8-induced [(³⁵)S]GTPγS binding (IC₅₀ = 60 nM), and suppresses ERK1/2 phosphorylation.
In vitro	SX-517 (0.1 nM-0.1 mM; 60 minutes) inhibited 10 nM CXCL8-induced [35S]GTPγS binding with an IC50 of 60 nM [1]. SX-517 (10 μM; 60 minutes) suppressed the cell surface expression of CXCR2 receptors in HEK293 cells [1]. SX-517 (10 μM; 0-30 minutes) blocked CXCR2-mediated ERK1/2 phosphorylation in HEK293 cells [1].
In vivo	SX-517 (0.02 mg/kg and 0.2 mg/kg) was administered via single intravenous injection to male CD1 SWISS mice bearing utetheisa ornatrix air pouches on their backs. The results demonstrated a significant reduction in cell counts within the utetheisa ornatrix air pouches of the mice [1].
Synonyms	SX517, SX 517

Chemical Properties

Molecular Weight	382.22
Formula	C₁₉H₁₆BFN₂O₃S
Cas No.	1240494-13-6
Smiles	O=C(NC1=CC=C(F)C=C1)C2=CN=C(SCC=3C=CC=CC3B(O)O)C=C2
Relative Density.	1.39 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (209.3 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (8.63 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6163 mL	13.0815 mL	26.1629 mL	130.8147 mL
5 mM	0.5233 mL	2.6163 mL	5.2326 mL	26.1629 mL
10 mM	0.2616 mL	1.3081 mL	2.6163 mL	13.0815 mL
20 mM	0.1308 mL	0.6541 mL	1.3081 mL	6.5407 mL
50 mM	0.0523 mL	0.2616 mL	0.5233 mL	2.6163 mL
100 mM	0.0262 mL	0.1308 mL	0.2616 mL	1.3081 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc