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UCB-9260

Name: UCB-9260
Brand: TargetMol
SKU: T13951
Price: 98 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T13951Cas No. 1515888-53-5

UCB-9260 inhibits TNF signaling by stabilizing an asymmetric form of the trimer.

UCB-9260

🥰Excellent

Purity: 99.24%

Catalog No. T13951Cas No. 1515888-53-5

UCB-9260 inhibits TNF signaling by stabilizing an asymmetric form of the trimer.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$98	In Stock	In Stock
2 mg	$143	In Stock	In Stock
5 mg	$243	In Stock	In Stock
10 mg	$392	In Stock	In Stock
25 mg	$668	In Stock	In Stock
50 mg	$892	-	In Stock
100 mg	$1,230	-	In Stock
200 mg	$1,650	-	In Stock
1 mL x 10 mM (in DMSO)	$272	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Purity:99.24%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	UCB-9260 inhibits TNF signaling by stabilizing an asymmetric form of the trimer.
Targets&IC50	NF-κB:202 nM, TNF (mouse):120 nM, TNF (human):116 nM
In vitro	In Hek-293 cells, UCB-9260 (0-10 μM)?inhibits NF-κB with a geometric mean IC50?of 202?nM after TNF (10?pM) stimulation. UCB-9260?inhibits TNF-dependent cytotoxicity with a geometric mean IC50?of 116?nM and a geometric mean IC50?of 120?nM, using human and mouse TNF, respectively.
In vivo	UCB-9260 (150?mg/kg; p.o.) treatment twice daily?for 7 days shows a significant reduction of the clinical score. In adult male Balb/c mice, UCB-9260?(10-300?mg/kg; p.o.) dose-dependently inhibits human and mouse TNF-induced neutrophil recruitment to the peritoneal compartment.

Chemical Properties

Molecular Weight	423.51
Formula	C₂₆H₂₅N₅O
Cas No.	1515888-53-5
Smiles	Cc1ccc(C)c(Cn2c(nc3ccc(cc23)-c2cnn(C)c2)C(O)c2ccncc2)c1
Relative Density.	1.25 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 81.7 mg/mL (192.91 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (11.81 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3612 mL	11.8061 mL	23.6122 mL	118.0610 mL
5 mM	0.4722 mL	2.3612 mL	4.7224 mL	23.6122 mL
10 mM	0.2361 mL	1.1806 mL	2.3612 mL	11.8061 mL
20 mM	0.1181 mL	0.5903 mL	1.1806 mL	5.9030 mL
50 mM	0.0472 mL	0.2361 mL	0.4722 mL	2.3612 mL
100 mM	0.0236 mL	0.1181 mL	0.2361 mL	1.1806 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc