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Anti-DR5/TRAIL R2 Antibody-PE (3K136)
🥰Excellent
Catalog No. TMAY-00864P
Anti-DR5/TRAIL R2 Antibody-PE (3K136) is a PE-conjugated Rabbit antibody targeting DR5/TRAIL R2. Anti-DR5/TRAIL R2 Antibody-PE (3K136) can be used in FCM.
Anti-DR5/TRAIL R2 Antibody-PE (3K136)
Anti-DR5/TRAIL R2 Antibody-PE (3K136)
🥰Excellent
Catalog No. TMAY-00864P
Anti-DR5/TRAIL R2 Antibody-PE (3K136) is a PE-conjugated Rabbit antibody targeting DR5/TRAIL R2. Anti-DR5/TRAIL R2 Antibody-PE (3K136) can be used in FCM.
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| Description | Anti-DR5/TRAIL R2 Antibody-PE (3K136) is a PE-conjugated Rabbit antibody targeting DR5/TRAIL R2. Anti-DR5/TRAIL R2 Antibody-PE (3K136) can be used in FCM. |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 3K136 |
| Reactivity | Human |
| Verified Activity | Profile of anti-TNFRSF10B (CD262) reactivity on Jurkat cells analyzed by flow cytometry. |
| Application | FCM |
| Recommended Dose | 10 μl/Test, 0.1 mg/ml |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human TRAIL R2 / TNFRSF10B / CD262 (rh TRAIL R2 / TNFRSF10B / CD262; TMPY-01185; NP_003833.4; Met 1-Glu 182) and conjugated with PE under optimum conditions, the unreacted PE was removed. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
| Research Background | Tumor necrosis factor receptor superfamily, member 10b, official symbol TNFRSF10B, also known as Death receptor 5, CD262, TNF-related apoptosis-inducing ligand receptor 2 (TRAIL R2), is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. TRAIL R2/CD262/TNFRSF10B was purified independently as the only receptor for TRAIL detectable on the surface of two different human cell lines that undergo apoptosis upon stimulation with TRAIL. TRAIL R2/CD262/TNFRSF10B contains two extracellular cysteine-rich repeats, typical for TNF receptor (TNFR) family members, and a cytoplasmic death domain. TRAIL R2/CD262/TNFRSF10B mediates apoptosis via the intracellular adaptor molecule FADD/MORT1. TRAIL receptors can signal both death and gene transcription, functions reminiscent of those of TNFR1 and TRAMP, two other members of the death receptor family. Defects in TRAIL R2/CD262/TNFRSF10B may be a cause of head and neck squamous cell carcinomas (HNSCC) also known as squamous cell carcinoma of the head and neck.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| Conjucates | PE |
| Others Formats | Unconjugated |
| Antibody Types Available | 2 |
| Immunogen | Recombinant Human TRAIL R2 / TNFRSF10B / CD262 protein (TMPY-01185) |
| Antigen Species | Human |
| Biology Area | Cancer Drug Targets |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. |
| Transport | Shipping with blue ice. |
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