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Calhex 231 hydrochloride
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Catalog No. T10666Cas No. 2387505-78-2
Alias Calhex231 hydrochloride
Calhex 231 hydrochloride is the salt form of Calhex 231, a potent calcium-sensing receptor (CaSR) negative-conversion modulator that blocks the increase in [3H]inositol phosphate, inhibits oxidative stress and mir-208a-mediated mitochondrial fission for vasculoprotection and treatment of traumatic hemorrhagic shock.
Calhex 231 hydrochloride
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Purity: 99.36%
Catalog No. T10666Alias Calhex231 hydrochlorideCas No. 2387505-78-2
Calhex 231 hydrochloride is the salt form of Calhex 231, a potent calcium-sensing receptor (CaSR) negative-conversion modulator that blocks the increase in [3H]inositol phosphate, inhibits oxidative stress and mir-208a-mediated mitochondrial fission for vasculoprotection and treatment of traumatic hemorrhagic shock.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $42 | - | In Stock | |
| 5 mg | $98 | - | In Stock | |
| 10 mg | $163 | - | In Stock | |
| 25 mg | Preferential | - | In Stock | |
| 50 mg | Preferential | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $108 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.36%
Appearance:Solid
Color:Yellow
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Product Introduction
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Storage & Solubility Information
| Description | Calhex 231 hydrochloride is the salt form of Calhex 231, a potent calcium-sensing receptor (CaSR) negative-conversion modulator that blocks the increase in [3H]inositol phosphate, inhibits oxidative stress and mir-208a-mediated mitochondrial fission for vasculoprotection and treatment of traumatic hemorrhagic shock. |
| Targets&IC50 | CaSR:0.39 μM |
| In vitro | Methods: LX-2 cells were treated with Calhex 231 hydrochloride (2.5, 5, 7.5, 10 μM, 48 hours), and cell viability was detected by MTT assay. Results: Calhex 231 hydrochloride could inhibit the growth of LX-2 cells, with an IC50 value of 9.5 μM. [4] |
| In vivo | Methods: Transverse aortic constriction (TAC) induced pressure overload and cardiac hypertrophy in male Wistar rats. Four weeks after TAC, rats were treated with Calhex 231 hydrochloride (10 μmol/kg, 4 weeks) for 4 weeks and analyzed 12 weeks after surgery. Rats were sacrificed and hearts were rapidly excised and weighed in cold (4 °C) buffer. The left and right ventricles were then isolated and weighed, and the left ventricular tissue was snap-frozen in liquid nitrogen and stored at -80 °C for subsequent western blot analysis. Results: Animals were observed to exhibit increases in interventricular septum (IVS) thickness, left ventricular posterior wall (LVPW) thickness, left ventricular internal dimension (LVID), left ventricular diastolic volume (LVDV), and left ventricular systolic volume (LVSV), as well as decreases in left ventricular fractional shortening (LVFS) and left ventricular ejection fraction (LVEF). [5] |
| Synonyms | Calhex231 hydrochloride |
| Molecular Weight | 443.41 |
| Formula | C25H28Cl2N2O |
| Cas No. | 2387505-78-2 |
| Smiles | [C@@H](N[C@@H]1[C@@H](NC(=O)C2=CC=C(Cl)C=C2)CCCC1)(C)C=3C4=C(C=CC3)C=CC=C4.Cl |
| Relative Density. | no data available |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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