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L-006235

Name: L-006235
Brand: TargetMol
SKU: T21616
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T21616Cas No. 294623-49-7

Alias L 006235

L-006235 is a potent and reversible inhibitor of cathepsin K with IC50 of 0.25 nM.

L-006235

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Purity: 99.37%

Catalog No. T21616Alias L 006235Cas No. 294623-49-7

L-006235 is a potent and reversible inhibitor of cathepsin K with IC50 of 0.25 nM.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$35	In Stock	In Stock
5 mg	$58	In Stock	In Stock
10 mg	$98	In Stock	In Stock
25 mg	$197	In Stock	In Stock
50 mg	$333	In Stock	In Stock
100 mg	$479	In Stock	In Stock
200 mg	$668	-	In Stock
1 mL x 10 mM (in DMSO)	$59	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.37%

Appearance:Solid

Color:White

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COA HNMR HPLC LCMS

Product Introduction

L-006235 AI Summary

L-006235 exhibits potent inhibitory activity against various cathepsins, including cathepsin K with an IC50 of 0.6 nM in humans and 0.25 nM in a humanized rabbit model. Its affinity for other cathepsins is moderate to low, with an IC50 of 1050.0 nM for cathepsin B, 3903.0 nM for cathepsin L, and greater than 10000.0 nM for cathepsin S. The compound also shows significant inhibition of in vitro bone resorption, demonstrated by an IC50 of 5.0 nM in an osteoclast bone resorption assay. Furthermore, in vivo studies in rats reveal a plasma concentration of 2.4 µM at 10 mg/kg po, a logP of 2.3, a pKa of 7.01, a volume of distribution (Vdss) of 11.0 L/kg, and an oral bioavailability (F) of 68.0% with a terminal half-life (T1/2) of 3.4 hours. L-006235 also impacts antigen presentation in mouse A20 cells, showing an IC50 of 6200.0 nM in IL-2 secretion assays. Additionally, it significantly reduces collagen breakdown products in ovariectomized rhesus monkeys at various dosages..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	L-006235 is a potent and reversible inhibitor of cathepsin K with IC50 of 0.25 nM.
Targets&IC50	Cathepsin K:5 nM (IC50)
Synonyms	L 006235

Chemical Properties

Molecular Weight	466.6
Formula	C₂₄H₃₀N₆O₂S
Cas No.	294623-49-7
Smiles	CN1CCN(CC1)c1nc(cs1)-c1ccc(cc1)C(=O)NC1(CCCCC1)C(=O)NCC#N
Relative Density.	1.31 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (107.16 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.29 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1432 mL	10.7158 mL	21.4316 mL	107.1582 mL
5 mM	0.4286 mL	2.1432 mL	4.2863 mL	21.4316 mL
10 mM	0.2143 mL	1.0716 mL	2.1432 mL	10.7158 mL
20 mM	0.1072 mL	0.5358 mL	1.0716 mL	5.3579 mL
50 mM	0.0429 mL	0.2143 mL	0.4286 mL	2.1432 mL
100 mM	0.0214 mL	0.1072 mL	0.2143 mL	1.0716 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc