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PDE4-IN-30
Catalog No. T214347 Copy Product Info
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PDE4-IN-30 is a selective PDE4 inhibitor with an IC50 of 2.7 nM for PDE4D2, targeting PDE4 through halogen bonding and metal coordination. It demonstrates at least 67 times greater selectivity for PDE4 compared to other PDE subfamilies and is applicable in research for idiopathic pulmonary fibrosis.
PDE4-IN-30
Copy Product Info🥰Excellent
Catalog No. T214347
PDE4-IN-30 is a selective PDE4 inhibitor with an IC50 of 2.7 nM for PDE4D2, targeting PDE4 through halogen bonding and metal coordination. It demonstrates at least 67 times greater selectivity for PDE4 compared to other PDE subfamilies and is applicable in research for idiopathic pulmonary fibrosis.
PDE4-IN-30
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | PDE4-IN-30 is a selective PDE4 inhibitor with an IC50 of 2.7 nM for PDE4D2, targeting PDE4 through halogen bonding and metal coordination. It demonstrates at least 67 times greater selectivity for PDE4 compared to other PDE subfamilies and is applicable in research for idiopathic pulmonary fibrosis. |
| Targets&IC50 | PDE4D2:2.7 nM |
| In vitro | PDE4-IN-30 (compound 13c), at concentrations of 5 μM to 20 μM for 48 hours, effectively inhibits TGF-β1-induced fibroblast-to-myofibroblast transition (FMT) and epithelial-mesenchymal transition (EMT) in MRC-5 and A549 cells. Additionally, it significantly suppresses TGF-β1-induced proliferation and migration of A549 cells at the same concentrations and duration. PDE4-IN-30 also demonstrates good cellular permeability and favorable drug-like properties in Caco-2 cells. |
| In vivo | PDE4-IN-30 (compound 13c), administered at 2.5 mg/kg via intraperitoneal injection for three weeks, has been shown to ameliorate lung fibrosis induced by Bleomycin (BLM) in C57BL/6J mice aged 6-8 weeks. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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