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BMS-566419

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Catalog No. T63246Cas No. 566161-24-8
Alias BMS566419, BMS 566419

BMS-566419 is an acridone-based inhibitor of inosine 5'-monophosphate dehydrogenase, a rate-limiting enzyme in de novo guanosine nucleotide biosynthesis, and through suppression of lymphocyte proliferation it has demonstrated clinical utility as a research compound for investigating immunosuppression mechanisms and therapeutic strategies in transplant rejection.

BMS-566419

BMS-566419

😃Good
Catalog No. T63246Alias BMS566419, BMS 566419Cas No. 566161-24-8
BMS-566419 is an acridone-based inhibitor of inosine 5'-monophosphate dehydrogenase, a rate-limiting enzyme in de novo guanosine nucleotide biosynthesis, and through suppression of lymphocyte proliferation it has demonstrated clinical utility as a research compound for investigating immunosuppression mechanisms and therapeutic strategies in transplant rejection.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
10 mg$89635 days35 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Product Introduction

Bioactivity
Description
BMS-566419 is an acridone-based inhibitor of inosine 5'-monophosphate dehydrogenase, a rate-limiting enzyme in de novo guanosine nucleotide biosynthesis, and through suppression of lymphocyte proliferation it has demonstrated clinical utility as a research compound for investigating immunosuppression mechanisms and therapeutic strategies in transplant rejection.
In vitro
In enzymatic assays, BMS-566419 specifically inhibited human IMPDH II with an IC50 of approximately 10 nM [1].
In vivo
In a rat model of Collagen-Induced Arthritis (CIA), oral administration of BMS-566419 reduced joint inflammation and disease progression. Pharmacokinetic studies demonstrated oral bioavailability for the compound [1].
SynonymsBMS566419, BMS 566419
Chemical Properties
Molecular Weight487.57
FormulaC28H30FN5O2
Cas No.566161-24-8
SmilesO=C(NC(C1=CN=C(C=C1)N2CCN(CC)CC2)(C)C)C=3C=C4NC=5C=CC=CC5C(=O)C4=CC3F
Storage & Solubility Information
StorageIn solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 10 mg/mL (20.51 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.0510 mL10.2549 mL20.5099 mL102.5494 mL
5 mM0.4102 mL2.0510 mL4.1020 mL20.5099 mL
10 mM0.2051 mL1.0255 mL2.0510 mL10.2549 mL
20 mM0.1025 mL0.5127 mL1.0255 mL5.1275 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
The above example illustrates how to use "In Vivo Formulation Calculator" and does not represent a recommended formulation for any specific compound. Please select an appropriate dissolution method based on your experimental animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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%
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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