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PD 168568 dihydrochloride

Name: PD 168568 dihydrochloride
Brand: TargetMol
SKU: T12383
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12383Cas No. 1782532-06-2

Alias PD 168568 (dihydrochloride)

PD 168568 dihydrochloride (PD 168568 (dihydrochloride)) is an orally active and selective antagonist of D4 dopamine receptor(Ki of 8.8 nM).

PD 168568 dihydrochloride

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Purity: 99.71%

Catalog No. T12383Alias PD 168568 (dihydrochloride)Cas No. 1782532-06-2

PD 168568 dihydrochloride (PD 168568 (dihydrochloride)) is an orally active and selective antagonist of D4 dopamine receptor(Ki of 8.8 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$40	In Stock	In Stock
10 mg	$53	In Stock	In Stock
25 mg	$119	In Stock	In Stock
50 mg	$178	In Stock	In Stock
100 mg	$260	In Stock	In Stock
200 mg	$366	-	In Stock
1 mL x 10 mM (in DMSO)	$55	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.71%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	PD 168568 dihydrochloride (PD 168568 (dihydrochloride)) is an orally active and selective antagonist of D4 dopamine receptor(Ki of 8.8 nM).
Targets&IC50	D4 receptor:8.8 nM (Ki), D2 Receptor:1842 nM (Ki), D3 receptor:2682 nM (Ki)
In vitro	PD 168568 dihydrochloride has good selective for D4 receptor(Ki of 1842 nM for D2 receptor)[1].
In vivo	PD 168568 dihydrochloride inhibit amphetamine stimulated locomotor activity in the rat[1].
Synonyms	PD 168568 (dihydrochloride)

Chemical Properties

Molecular Weight	422.39
Formula	C₂₂H₂₉Cl₂N₃O
Cas No.	1782532-06-2
Smiles	O=C1NC(CCN2CCN(CC2)C3=CC=C(C)C(C)=C3)C4=C1C=CC=C4.Cl.Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (130.21 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3675 mL	11.8374 mL	23.6748 mL	118.3740 mL
5 mM	0.4735 mL	2.3675 mL	4.7350 mL	23.6748 mL
10 mM	0.2367 mL	1.1837 mL	2.3675 mL	11.8374 mL
20 mM	0.1184 mL	0.5919 mL	1.1837 mL	5.9187 mL
50 mM	0.0473 mL	0.2367 mL	0.4735 mL	2.3675 mL
100 mM	0.0237 mL	0.1184 mL	0.2367 mL	1.1837 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc