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Dimethyl-SGD-1882
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Catalog No. T11046Cas No. 3026416-27-0
Alias Dimethyl-PBD dimer
Dimethyl-SGD-1882 (Dimethyl-PBD dimer) is a highly efficient DNA alkylating agent used as an antibody-drug conjugate (ADC) cytotoxin, inhibiting DNA replication.
Dimethyl-SGD-1882
😃Good
Catalog No. T11046Alias Dimethyl-PBD dimerCas No. 3026416-27-0
Dimethyl-SGD-1882 (Dimethyl-PBD dimer) is a highly efficient DNA alkylating agent used as an antibody-drug conjugate (ADC) cytotoxin, inhibiting DNA replication.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $3,170 | 3-6 months | 3-6 months | |
| 50 mg | $4,180 | 3-6 months | 3-6 months | |
| 100 mg | $5,800 | 3-6 months | 3-6 months |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
| Description | Dimethyl-SGD-1882 (Dimethyl-PBD dimer) is a highly efficient DNA alkylating agent used as an antibody-drug conjugate (ADC) cytotoxin, inhibiting DNA replication. |
| In vitro | The unique structure of Pyrrolobenzodiazepine (PBD) dimer contains two alkylated imines. In addition to monoalkylated adducts, it can also form inter-chain or intra-chain DNA cross-links, therefore Compared with PBD, it has greater DNA stability. Due to the possibility of other types of DNA adducts and higher adduct stability, C8-linked PBD dimers usually have significantly higher cytotoxicity, antitumor activity, and antibacterial activity than PBD monomers And one of the reagents, SJG-136, has entered clinical trials for stage II ovarian cancer and leukemia. In addition, because the related PBD dimer has significant cytotoxicity, it is currently being used as a payload of antibody-drug conjugates (ADC). |
| Synonyms | Dimethyl-PBD dimer |
| Molecular Weight | 753.84 |
| Formula | C44H43N5O7 |
| Cas No. | 3026416-27-0 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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