RGMB Protein, Human, Recombinant (hFc)

Name: RGMB Protein, Human, Recombinant (hFc)
Brand: TargetMol
SKU: TMPY-07146
Rating: 4.5 (1 reviews)

(Synonyms: FLJ90406, DRAGON) Copy Product Info

Synonyms: FLJ90406, DRAGON

Catalog No. TMPY-07146 Copy Product Info

RGMB Protein, Human, Recombinant (hFc) is expressed in HEK293 Cells. The accession number is Q6NW40.

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Pack Size	Price	USA Stock	Global Stock
5 µg	$77	7-10 days	7-10 days
10 µg	$126	7-10 days	7-10 days
20 µg	$198	7-10 days	7-10 days
50 µg	$397	7-10 days	7-10 days
100 µg	$796	7-10 days	7-10 days
200 µg	$1,200	7-10 days	7-10 days
500 µg	$2,590	7-10 days	7-10 days
1 mg	$5,280	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Immobilized BMP4 Protein, Human, Recombinant (E399D) (Cat#TMPY-06842) at 2 μg/mL (100 μL/well) can bind RGMB Protein, Human, Recombinant (hFc) (Cat#TMPY-07146) with a linear range of 0.16-4 ug/mL.
Description	RGMB Protein, Human, Recombinant (hFc) is expressed in HEK293 Cells. The accession number is Q6NW40.
Species	Human
Expression System	HEK293 Cells
Tag	C-hFc
Accession Number	Q6NW40
Construction	A DNA sequence encoding the Human RGMB (NP_001012779.2) (Met1-Asn413) was expressed with the Fc region of human IgG1 at the C-terminus.
Protein Purity	≥ 95% as determined by SDS-PAGE. ≥ 95% as determined by SEC-HPLC.
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Please refer to the lot-specific COA.
Synonyms	FLJ90406, DRAGON
Research Background	RGMB was knocked down in breast cancer cells by way of an anti-RGMB ribozyme transgene. Knockdown of RGMB resulted in enhanced capacities of proliferation, adhesion, and migration in breast cancer cells. Further investigations demonstrated RGMB knockdown resulted in a reduced expression and activity of Caspase-3, accompanied with better survival in RGMB knockdown cells under serum starvation, which might be induced by its repression on MAPK JNK pathway. That RGMB may act as a negative regulator in breast cancer through BMP signaling.

Chemical Properties

Molecular Weight

67.26 kDa (predicted); 63.2 kDa and 20 kDa (reducing contition)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.