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DMT1 blocker 2

Name: DMT1 blocker 2
Brand: TargetMol
SKU: T11064
Price: 84 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11064Cas No. 1062648-63-8

DMT1 blocker 2, compound 12f, is a direct inhibitor of divalent metal transporter 1 (DMT1) with an IC50 hydrogen peroxide value of 0.83, which is expected to block iron uptake by intestinal epithelial cells in vivo.

DMT1 blocker 2

🥰Excellent

Purity: 99.68%

Catalog No. T11064Cas No. 1062648-63-8

Pack Size	Price	Availability
1 mg	$84	In Stock
5 mg	$198	In Stock
10 mg	$372	In Stock
25 mg	$629	In Stock
50 mg	$896	In Stock
100 mg	$1,220	In Stock
1 mL x 10 mM (in DMSO)	$226	In Stock

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Batch Information

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Purity:99.68%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	DMT1 blocker 2, compound 12f, is a direct inhibitor of divalent metal transporter 1 (DMT1) with an IC50 hydrogen peroxide value of 0.83, which is expected to block iron uptake by intestinal epithelial cells in vivo.
Targets&IC50	DMT1:0.83μM
In vitro	IC50: 0.83 μM (DMT1 blocker 2)

Chemical Properties

Molecular Weight	263.29
Formula	C₁₆H₁₃N₃O
Cas No.	1062648-63-8
Smiles	Oc1c-2c(CCc3ccccc-23)nn1-c1ccccn1
Relative Density.	1.35 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 48 mg/mL (182.3 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7981 mL	18.9905 mL	37.9809 mL	189.9047 mL
5 mM	0.7596 mL	3.7981 mL	7.5962 mL	37.9809 mL
10 mM	0.3798 mL	1.8990 mL	3.7981 mL	18.9905 mL
20 mM	0.1899 mL	0.9495 mL	1.8990 mL	9.4952 mL
50 mM	0.0760 mL	0.3798 mL	0.7596 mL	3.7981 mL
100 mM	0.0380 mL	0.1899 mL	0.3798 mL	1.8990 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc