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JK-P3

Name: JK-P3
Brand: TargetMol
SKU: T4425
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4425Cas No. 942655-44-9

JK-P3 is a pyrazole-based inhibitor of VEGFR-2 (IC50: 7.8 μM). JK-P3 inhibits FGFR 1/3 kinase activity in vitro, but has no effect on FGFR signaling in cell-based assays. The compound blocks wound healing and tube formation in HUVEC without effecting endothelial cell proliferation.

JK-P3

🥰Excellent

Purity: 99.57%

Catalog No. T4425Cas No. 942655-44-9

Pack Size	Price	Availability
10 mg	$41	In Stock
25 mg	$93	In Stock
50 mg	$167	In Stock
100 mg	$247	In Stock
200 mg	$345	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock

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Purity:99.57%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	JK-P3 is a pyrazole-based inhibitor of VEGFR-2 (IC50: 7.8 μM). JK-P3 inhibits FGFR 1/3 kinase activity in vitro, but has no effect on FGFR signaling in cell-based assays. The compound blocks wound healing and tube formation in HUVEC without effecting endothelial cell proliferation.
Targets&IC50	VEGFR2:7.8 μM, FGFR1:27 μM, FGFR3:5.18 μM

Chemical Properties

Molecular Weight	323.35
Formula	C₁₈H₁₇N₃O₃
Cas No.	942655-44-9
Smiles	COc1ccc(cc1OC)C(=O)Nc1cc([nH]n1)-c1ccccc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (185.56 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.19 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0926 mL	15.4631 mL	30.9262 mL	154.6312 mL
5 mM	0.6185 mL	3.0926 mL	6.1852 mL	30.9262 mL
10 mM	0.3093 mL	1.5463 mL	3.0926 mL	15.4631 mL
20 mM	0.1546 mL	0.7732 mL	1.5463 mL	7.7316 mL
50 mM	0.0619 mL	0.3093 mL	0.6185 mL	3.0926 mL
100 mM	0.0309 mL	0.1546 mL	0.3093 mL	1.5463 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc