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MC2590
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Catalog No. T73515Cas No. 2284460-01-9
MC2590 is a potent and selective histone deacetylase (HDAC) inhibitor that inhibits HDAC1-3, -6, -8, and -10 activities, induces cell cycle arrest, and promotes apoptosis.
MC2590
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Purity: 99.64%
Catalog No. T73515Cas No. 2284460-01-9
MC2590 is a potent and selective histone deacetylase (HDAC) inhibitor that inhibits HDAC1-3, -6, -8, and -10 activities, induces cell cycle arrest, and promotes apoptosis.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $347 | In Stock | In Stock | |
| 5 mg | $689 | In Stock | In Stock | |
| 10 mg | $982 | - | In Stock | |
| 25 mg | $1,570 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Purity:99.64%
Appearance:Solid
Color:Yellow
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | MC2590 is a potent and selective histone deacetylase (HDAC) inhibitor that inhibits HDAC1-3, -6, -8, and -10 activities, induces cell cycle arrest, and promotes apoptosis. |
| Targets&IC50 | HDAC6:0.015 μM, K562 cells:0.05 μM, HDAC8:0.047 μM, HDAC10:0.071 μM, HDAC11:3.98 μM, HDAC3:0.039 μM, HDAC5:1.35 μM, HDAC9:2.79 μM, HDAC7:2.06 μM, HDAC4:2.73 μM, HDAC1:0.098 μM, HCT116 cells:0.07 μM, HDAC2:0.156 μM, A549 cells:0.32 μM |
| In vitro | MC2625/MC2590 (Compound 5e), over 72 hours, inhibits colorectal cancer cells HCT116 (IC50=0.07 μM), lung adenocarcinoma cells A549 (IC50=0.32 μM), and chronic myeloid leukemia cells K562 (IC50=0.05 μM) [1].At concentrations of 1 and 5 μM over 24 and 48 hours, MC2625/MC2590 induces G2/M cell cycle arrest [1]. At concentrations of 1 and 5 μM over 24 and 48 hours, MC2625/MC2590 induces excessive acetylation activity of H3K9/14, increases acetylated-α-tubulin levels, and significantly upregulates p21 protein [1].At concentrations of 1 and 5 μM over 48 hours, MC2625/MC2590 increases mRNA expression of p21, BAX, and BAK, downregulates cell cycle proteins D1 and BCL-2, and modulates pro-apoptotic and anti-apoptotic microRNAs to induce apoptosis [1]. |
| Molecular Weight | 347.37 |
| Formula | C20H17N3O3 |
| Cas No. | 2284460-01-9 |
| Smiles | C(C(NC=1C=CC(C=CC(NO)=O)=NC1)=O)C=2C3=C(C=CC2)C=CC=C3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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