Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MC2590 is a potent and selective histone deacetylase (HDAC) inhibitor that inhibits HDAC1-3, -6, -8, and -10 activities, induces cell cycle arrest, and promotes apoptosis.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 518.00 | |
5 mg | In stock | $ 1,170.00 | |
25 mg | In stock | $ 1,920.00 | |
50 mg | In stock | $ 2,380.00 | |
100 mg | In stock | $ 3,100.00 |
Description | MC2590 is a potent and selective histone deacetylase (HDAC) inhibitor that inhibits HDAC1-3, -6, -8, and -10 activities, induces cell cycle arrest, and promotes apoptosis. |
Targets&IC50 | A549 cells:0.32 μM, HDAC2:0.156 μM, HDAC8:0.047 μM, K562:0.05 μM, HDAC3:0.039 μM, HDAC6:0.015 μM, HCT116 cells:0.07 μM, HDAC10:0.071 μM, HDAC1:0.098 μM |
In vitro |
MC2625/MC2590 (Compound 5e), over 72 hours, inhibits colorectal cancer cells HCT116 (IC50=0.07 μM), lung adenocarcinoma cells A549 (IC50=0.32 μM), and chronic myeloid leukemia cells K562 (IC50=0.05 μM) [1].At concentrations of 1 and 5 μM over 24 and 48 hours, MC2625/MC2590 induces G2/M cell cycle arrest [1]. At concentrations of 1 and 5 μM over 24 and 48 hours, MC2625/MC2590 induces excessive acetylation activity of H3K9/14, increases acetylated-α-tubulin levels, and significantly upregulates p21 protein [1].At concentrations of 1 and 5 μM over 48 hours, MC2625/MC2590 increases mRNA expression of p21, BAX, and BAK, downregulates cell cycle proteins D1 and BCL-2, and modulates pro-apoptotic and anti-apoptotic microRNAs to induce apoptosis [1]. |
Molecular Weight | 347.37 |
Formula | C20H17N3O3 |
CAS No. | 2284460-01-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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MC2590 2284460-01-9 Apoptosis Chromatin/Epigenetic DNA Damage/DNA Repair HDAC inhibitor inhibit