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Ro 46-2005

Name: Ro 46-2005
Brand: TargetMol
SKU: T3194
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3194Cas No. 150725-87-4

Ro 46-2005 is a synthetic non-peptide endothelin receptor antagonist, inhibits the specific binding of 125I-ET-1 to human vascular smooth muscle cells (ETA receptor, IC50: 220 nM).

Ro 46-2005

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Purity: 98.8%

Catalog No. T3194Cas No. 150725-87-4

Ro 46-2005 is a synthetic non-peptide endothelin receptor antagonist, inhibits the specific binding of 125I-ET-1 to human vascular smooth muscle cells (ETA receptor, IC50: 220 nM).

Pack Size	Price	Availability
5 mg	$38	In Stock
10 mg	$73	In Stock
25 mg	$133	In Stock
50 mg	$223	In Stock
100 mg	$319	In Stock
200 mg	$461	In Stock
1 mL x 10 mM (in DMSO)	$42	In Stock

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Batch Information

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Purity:98.8%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Ro 46-2005 is a synthetic non-peptide endothelin receptor antagonist, inhibits the specific binding of 125I-ET-1 to human vascular smooth muscle cells (ETA receptor, IC50: 220 nM).
Targets&IC50	ETA receptor:220 nM

Chemical Properties

Molecular Weight	473.54
Formula	C₂₃H₂₇N₃O₆S
Cas No.	150725-87-4
Smiles	COc1cccc(Oc2c(NS(=O)(=O)c3ccc(cc3)C(C)(C)C)ncnc2OCCO)c1
Relative Density.	1.299 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (105.59 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1118 mL	10.5588 mL	21.1175 mL	105.5877 mL
5 mM	0.4224 mL	2.1118 mL	4.2235 mL	21.1175 mL
10 mM	0.2112 mL	1.0559 mL	2.1118 mL	10.5588 mL
20 mM	0.1056 mL	0.5279 mL	1.0559 mL	5.2794 mL
50 mM	0.0422 mL	0.2112 mL	0.4224 mL	2.1118 mL
100 mM	0.0211 mL	0.1056 mL	0.2112 mL	1.0559 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc