Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AChE/Aβ-IN-1 (compound 32) is a potent, orally active acetylcholinesterase (AChE) inhibitor with an IC50 of 86 nM and an NMDA receptor antagonist targeting the GluN1-1b/GluN2B subunit combination with an IC50 of 3.876 μM. Additionally, it impedes Aβ aggregation, exhibits favorable blood-brain barrier permeability, offers neuroprotection, and enhances cognitive and spatial memory in rat models [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | Inquiry | Inquiry | |
50 mg | Inquiry | Inquiry |
Description | AChE/Aβ-IN-1 (compound 32) is a potent, orally active acetylcholinesterase (AChE) inhibitor with an IC50 of 86 nM and an NMDA receptor antagonist targeting the GluN1-1b/GluN2B subunit combination with an IC50 of 3.876 μM. Additionally, it impedes Aβ aggregation, exhibits favorable blood-brain barrier permeability, offers neuroprotection, and enhances cognitive and spatial memory in rat models [1]. |
In vitro | AChE/Aβ-IN-1 (compound 32) at concentrations of 5-20 μM over 48 hours inhibits the aggregation of Aβ1-42 (10 μM) [1]. |
In vivo | Compound 32, designated as AChE/Aβ-IN-1, at a dosage of 10 mg/kg/day administered orally for 7 days, mitigated memory deficits in rats induced by Aβ1-42 and decreased the time spent in the platform area of the Morris Water Maze [1]. |
Molecular Weight | 401.34 |
Formula | C20H25BrN4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
AChE/Aβ-IN-1 inhibitor inhibit