Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Keap1-Nrf2-IN-4, a powerful neddylation inhibitor, demonstrates significant anti-proliferation activity against MGC-803 cells (IC50 = 2.55 μM), effectively impeding their migration and inducing apoptosis. Additionally, it effectively inhibits tumor growth while exhibiting minimal toxicity [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 10-14 weeks | $ 1,520.00 | |
50 mg | 10-14 weeks | $ 1,980.00 | |
100 mg | 10-14 weeks | $ 2,500.00 |
Description | Keap1-Nrf2-IN-4, a powerful neddylation inhibitor, demonstrates significant anti-proliferation activity against MGC-803 cells (IC50 = 2.55 μM), effectively impeding their migration and inducing apoptosis. Additionally, it effectively inhibits tumor growth while exhibiting minimal toxicity [1]. |
In vitro | Keap1-Nrf2-IN-4 (compound 4g) demonstrates significant anti-proliferative effects, exhibiting IC50 values of 2.55, 3.88, 3.74, and 2.89 μM in MGC-803, MCF-7, A549, and HepG-2 cell lines, respectively, after 72 hours of treatment. Additionally, this compound effectively inhibits the neddylation of cullin1, cullin3, and cullin5, and obstructs the migratory ability of MGC-803 cells without causing cell cycle arrest. When applied for 24 and 48 hours, Keap1-Nrf2-IN-4 induces apoptosis in MGC-803 and HGC-27 cells in both concentration- and time-dependent manners, highlighting its potential as a therapeutic agent in cancer treatment. |
In vivo | Keap1-Nrf2-IN-4, administered orally at dosages of 50 and 100 mg/kg daily for a duration of 21 days, demonstrated effective antitumor activity in a xenograft model utilizing 5-6 weeks old, 18-20 g NOD SCID mice, without manifesting any evident adverse effects [1]. |
Molecular Weight | 390.56 |
Formula | C26H34N2O |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Keap1-Nrf2-IN-4 inhibitor inhibit