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Diclone

Name: Diclone
Brand: TargetMol
SKU: T7074
Rating: 4.5 (1 reviews)

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Catalog No. T7074Cas No. 117-80-6

2, 3-Dichloro-1, 4-naphthoquinone is an inhibitor of Itch, a HECT domain-E3 ligase. It is also used in pesticide formulations.

Diclone

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Purity: 99.02%

Catalog No. T7074Cas No. 117-80-6

2, 3-Dichloro-1, 4-naphthoquinone is an inhibitor of Itch, a HECT domain-E3 ligase. It is also used in pesticide formulations.

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Purity:99.02%

Resource Download

COA HNMR HPLC

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description

2, 3-Dichloro-1, 4-naphthoquinone is an inhibitor of Itch, a HECT domain-E3 ligase. It is also used in pesticide formulations.

Chemical Properties

Molecular Weight	227.04
Formula	C₁₀H₄Cl₂O₂
Cas No.	117-80-6
Smiles	ClC1=C(Cl)C(=O)C2=C(C=CC=C2)C1=O

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 22.5 mg/mL (99.1 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.4045 mL	22.0226 mL	44.0451 mL	220.2255 mL
5 mM	0.8809 mL	4.4045 mL	8.8090 mL	44.0451 mL
10 mM	0.4405 mL	2.2023 mL	4.4045 mL	22.0226 mL
20 mM	0.2202 mL	1.1011 mL	2.2023 mL	11.0113 mL
50 mM	0.0881 mL	0.4405 mL	0.8809 mL	4.4045 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

ubiquitin E3 ligase HECTD2Diclone