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Anti-human CD47 Antibody (3B549)

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Catalog No. TMAB-07412

Anti-human CD47 Antibody (3B549) is a Mouse antibody targeting human CD47. Anti-human CD47 Antibody (3B549) can be used in FCM.

Anti-human CD47 Antibody (3B549)

Anti-human CD47 Antibody (3B549)

😃Good
Catalog No. TMAB-07412
Anti-human CD47 Antibody (3B549) is a Mouse antibody targeting human CD47. Anti-human CD47 Antibody (3B549) can be used in FCM.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
100 μg$3557-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-human CD47 Antibody (3B549) is a Mouse antibody targeting human CD47. Anti-human CD47 Antibody (3B549) can be used in FCM.
Ig Type
Mouse IgG1, k
Clone
3B549
Reactivity
Human
Application
Recommended Dose
FCM: 1:50-100
Antibody Type
Monoclonal
Host SpeciesMouse
Subcellular LocalizationCell membrane; Multi-pass membrane protein.
Tissue SpecificityVery broadly distributed on normal adult tissues, as well as ovarian tumors, being especially abundant in some epithelia and the brain.
ConstructionHybridoma Monoclonal Antibody
PurificationProtein G purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4).
Research BackgroundThis gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. This gene has broad tissue distribution, and is reduced in expression on Rh erythrocytes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2010]
Antigen Details
Gene Name
CD47
Gene ID
Protein Name
Leukocyte surface antigen CD47
Function
Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection.
Chemical Properties
Molecular WeightTheoretical: 33 kDa. Actual: 42-52 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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