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H-Leu-Leu-OMe . HBr

Name: H-Leu-Leu-OMe . HBr
Brand: TargetMol
SKU: T36879L
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T36879L

Alias H-Leu-Leu-OMe . HBr (16689-14-8 Free base)

H-Leu-Leu-OMe . HBr is a dipeptide condensation product of L-leucine methyl ester generated by human monocytes or polymorphonuclear leukocytes. H-Leu-Leu-OMe . HBr induces endolysosomal pathway stress and selectively eliminates lymphocytes with cytotoxic potential.

H-Leu-Leu-OMe . HBr

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Purity: 98.91%

Catalog No. T36879LAlias H-Leu-Leu-OMe . HBr (16689-14-8 Free base)

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$30	-	In Stock
10 mg	$45	-	In Stock
25 mg	$81	-	In Stock
50 mg	$118	-	In Stock
100 mg	$178	-	In Stock
1 mL x 10 mM (in DMSO)	$44	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:98.91%

Resource Download

COA MS HPLC

Product Introduction

Bioactivity

Description	H-Leu-Leu-OMe . HBr is a dipeptide condensation product of L-leucine methyl ester generated by human monocytes or polymorphonuclear leukocytes. H-Leu-Leu-OMe . HBr induces endolysosomal pathway stress and selectively eliminates lymphocytes with cytotoxic potential.
In vitro	H-Leu-Leu-OMe . HBr (10-250 μM; 15 min) is converted to a CCI3COOH-insoluble product by CD4- lymphocytes[1]. H-Leu-Leu-OMe . HBr (1 mM; 0.5-2 h) enhances LRRK2-mediated Rab10 and Rab12 phosphorylation in MEFs and A549 cells[2].
Synonyms	H-Leu-Leu-OMe . HBr (16689-14-8 Free base)

Chemical Properties

Molecular Weight	399.32
Formula	C₁₅H₃₁BrN₂O₅
Smiles	CC(O)=O.O=C(OC)[C@@H](CC(C)C)NC([C@@H](N)CC(C)C)=O.Br
Sequence	Leu-Leu
Sequence Short	LL

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (112.69 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5043 mL	12.5213 mL	25.0426 mL	125.2129 mL
5 mM	0.5009 mL	2.5043 mL	5.0085 mL	25.0426 mL
10 mM	0.2504 mL	1.2521 mL	2.5043 mL	12.5213 mL
20 mM	0.1252 mL	0.6261 mL	1.2521 mL	6.2606 mL
50 mM	0.0501 mL	0.2504 mL	0.5009 mL	2.5043 mL
100 mM	0.0250 mL	0.1252 mL	0.2504 mL	1.2521 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc