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H-Leu-Leu-OMe . HBr

Catalog No. T36879L

Synonyms: H-Leu-Leu-OMe . HBr (16689-14-8 Free base)

H-Leu-Leu-OMe . HBr is a dipeptide condensation product of L-leucine methyl ester generated by human monocytes or polymorphonuclear leukocytes. H-Leu-Leu-OMe . HBr induces endolysosomal pathway stress and selectively eliminates lymphocytes with cytotoxic potential.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

H-Leu-Leu-OMe . HBr, CAS N/A

Pack Size	Availability	Price/USD
5 mg	In stock	$ 50.00
10 mg	In stock	$ 75.00
25 mg	In stock	$ 135.00
50 mg	In stock	$ 197.00
100 mg	In stock	$ 297.00
200 mg	In stock	$ 456.00
1 mL * 10 mM (in DMSO)	In stock	$ 74.00

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Purity: 98.91%

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Storage & Solubility Information

Description	H-Leu-Leu-OMe . HBr is a dipeptide condensation product of L-leucine methyl ester generated by human monocytes or polymorphonuclear leukocytes. H-Leu-Leu-OMe . HBr induces endolysosomal pathway stress and selectively eliminates lymphocytes with cytotoxic potential.
In vitro	H-Leu-Leu-OMe . HBr (10-250 μM; 15 min) is converted to a CCI3COOH-insoluble product by CD4- lymphocytes[1]. H-Leu-Leu-OMe . HBr (1 mM; 0.5-2 h) enhances LRRK2-mediated Rab10 and Rab12 phosphorylation in MEFs and A549 cells[2].

Synonyms	H-Leu-Leu-OMe . HBr (16689-14-8 Free base)
Molecular Weight	399.32
Formula	C15H31BrN2O5

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45 mg/mL (112.69 mM)

References and Literature

1. Thiele DL, et, al. Mechanism of L-leucyl-L-leucine methyl ester-mediated killing of cytotoxic lymphocytes: dependence on a lysosomal thiol protease, dipeptidyl peptidase I, that is enriched in these cells. Proc Natl Acad Sci U S A. 1990 Jan;87(1):83-7. 2. Kalogeropulou AF, et, al. Endogenous Rab29 does not impact basal or stimulated LRRK2 pathway activity. Biochem J. 2020 Nov 27;477(22):4397-4423. 3. Thiele DL, et, al. The immunosuppressive activity of L-leucyl-L-leucine methyl ester: selective ablation of cytotoxic lymphocytes and monocytes. J Immunol. 1986 Feb 1;136(3):1038-48.

Related compound libraries

This product is contained In the following compound libraries：

Peptide Compound Library Bioactive Compounds Library Max Bioactive Compound Library

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Keywords

H-Leu-Leu-OMe . HBr Others 16689-14-8 Free base HLeuLeuOMe . HBr 16689-14-8 H Leu Leu OMe . HBr H-Leu-Leu-OMe . HBr (16689-14-8 Free base) inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.