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Secnidazole
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Catalog No. T0195Cas No. 3366-95-8
Alias RP-14539, PM-185184
Secnidazole (PM-185184) is a second-generation 5-nitroimidazole antimicrobial that is structurally related to other 5-nitroimidazoles including [DB00916] and [DB00911], but displays improved oral absorption and longer terminal elimination half-life than antimicrobial agents in this class [A27210]. Secnidazole is selective against many anaerobic Gram-positive and Gram-negative bacteria and protozoa.
Secnidazole
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Purity: 98.86%
Catalog No. T0195Alias RP-14539, PM-185184Cas No. 3366-95-8
Secnidazole (PM-185184) is a second-generation 5-nitroimidazole antimicrobial that is structurally related to other 5-nitroimidazoles including [DB00916] and [DB00911], but displays improved oral absorption and longer terminal elimination half-life than antimicrobial agents in this class [A27210]. Secnidazole is selective against many anaerobic Gram-positive and Gram-negative bacteria and protozoa.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $34 | In Stock | In Stock | |
| 10 mg | $50 | In Stock | In Stock | |
| 25 mg | $58 | In Stock | In Stock | |
| 50 mg | $90 | In Stock | In Stock | |
| 100 mg | $108 | In Stock | In Stock | |
| 200 mg | $129 | In Stock | In Stock | |
| 500 mg | $156 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $42 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:98.86%
Appearance:Solid
Color:White
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Product Introduction
Secnidazole AI Summary
Secnidazole exhibits a broad range of biological activities with potential therapeutic applications. It shows antitrichomonas activity against Trichomonas vaginalis TVR87 with an IC50 of 810.0 nM and a high specificity index, indicating minimal cytotoxicity to human THP1 cells. It has no mutagenic effects in Salmonella Typhimurium YG1042 and TA100 strains. The compound acts as an inhibitor for various cellular targets and pathways, including ERK signaling, malarial parasite plastid delayed death, HCV replication, TDP-43, MBNL1-poly(CUG) RNA binding, and Ebola virus entry. It also inhibits N-terminal His-tagged Escherichia coli FabH with an IC50 of 28500.0 nM and shows low toxicity in erythrocytes. Secnidazole demonstrates potent inhibition of OATP1B3 and OATP1B1 transporters.
Additionally, the compound exhibits cytotoxicity against several cell types and inhibits the proliferation of a range of pathogens, including Giardia intestinalis and Bacteroides fragilis with a MIC of 800.0 nM. It has antiparasitic activity against human African trypanosomiasis and shows antifungal and antibacterial properties against pathogens such as Candida albicans and Cryptococcus neoformans. The compound also demonstrates antiviral activity against SARS-CoV-2 by reducing cytotoxicity in various cell models, although its effectiveness varies depending on the assay conditions.
Secnidazole inhibits human HDAC6 enzyme activity and shows antigiardial activity against Giardia intestinalis with an IC50 of 4410.0 nM. Collectively, these findings suggest that Secnidazole has diverse bioactivities with potential implications for treating multiple diseases, including infections caused by viruses, bacteria, fungi, parasites, and certain human cell pathologies..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Secnidazole (PM-185184) is a second-generation 5-nitroimidazole antimicrobial that is structurally related to other 5-nitroimidazoles including [DB00916] and [DB00911], but displays improved oral absorption and longer terminal elimination half-life than antimicrobial agents in this class [A27210]. Secnidazole is selective against many anaerobic Gram-positive and Gram-negative bacteria and protozoa. |
| Synonyms | RP-14539, PM-185184 |
| Molecular Weight | 185.18 |
| Formula | C7H11N3O3 |
| Cas No. | 3366-95-8 |
| Smiles | CC(O)CN1C(C)=NC=C1[N+]([O-])=O |
| Relative Density. | 1.39g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 34 mg/mL (183.61 mM), Sonication is recommended. Ethanol: 35 mg/mL (189.01 mM), Sonication is recommended. DMSO: 60 mg/mL (324.01 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O/Ethanol/DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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