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UNC0321

Name: UNC0321
Brand: TargetMol
SKU: T17204
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T17204Cas No. 1238673-32-9

UNC0321 is an effective inhibitor of histone methyltransferase G9a with a Ki of 63 pM and with IC50s 9 nM and 6 nM in ECSD and CLOT assays. UNC0321 inhibits GLP with IC50s of 15 nM and 23 nM in ECSD and CLOT assays.

UNC0321

🥰Excellent

Purity: 99.80%

Catalog No. T17204Cas No. 1238673-32-9

Pack Size	Price	Availability
1 mg	$39	In Stock
5 mg	$94	In Stock
10 mg	$147	In Stock
25 mg	$289	In Stock
50 mg	$455	In Stock
100 mg	$655	In Stock

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Purity:99.80%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	UNC0321 is an effective inhibitor of histone methyltransferase G9a with a Ki of 63 pM and with IC50s 9 nM and 6 nM in ECSD and CLOT assays. UNC0321 inhibits GLP with IC50s of 15 nM and 23 nM in ECSD and CLOT assays.
Targets&IC50	G9a:6-9 nM, GLP:15-23 nM, G9a:63 pM （ki）
In vitro	UNC0321 is inactive against SET7/9, SET8/PreSET7, PRMT3 and JMJD2E[1]. UNC0321 reduces H3K9me2 levels in MDA-MB-231 cells with an IC50 of 11 μM[2].

Chemical Properties

Molecular Weight	515.69
Formula	C₂₇H₄₅N₇O₃
Cas No.	1238673-32-9
Smiles	COc1cc2c(NC3CCN(C)CC3)nc(nc2cc1OCCOCCN(C)C)N1CCCN(C)CC1
Relative Density.	1.150 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 3.33 mg/ml (6.46 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9391 mL	9.6957 mL	19.3915 mL	96.9575 mL
5 mM	0.3878 mL	1.9391 mL	3.8783 mL	19.3915 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc