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Anti-TLT-1/TREML1 Antibody (3P589)
🥰Excellent
Catalog No. TMAY-02153
Anti-TLT-1/TREML1 Antibody (3P589) is a Mouse antibody targeting TLT-1/TREML1. Anti-TLT-1/TREML1 Antibody (3P589) can be used in ELISA(Cap).
Anti-TLT-1/TREML1 Antibody (3P589)
Anti-TLT-1/TREML1 Antibody (3P589)
🥰Excellent
Catalog No. TMAY-02153
Anti-TLT-1/TREML1 Antibody (3P589) is a Mouse antibody targeting TLT-1/TREML1. Anti-TLT-1/TREML1 Antibody (3P589) can be used in ELISA(Cap).
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-TLT-1/TREML1 Antibody (3P589) is a Mouse antibody targeting TLT-1/TREML1. Anti-TLT-1/TREML1 Antibody (3P589) can be used in ELISA(Cap). |
| Ig Type | Monoclonal Mouse IgG1 |
| Clone | 3P589 |
| Reactivity | Human |
| Application | ELISA(Cap) |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human TLT-1 / TREML1 (rh TLT-1 / TREML1; TMPY-01840; Q86YW5-1; Met1-Pro162). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Trem-like transcript 1 protein, also known as Triggering receptor expressed on myeloid cells-like protein 1, TREML1 and TLT-1, is a cytoplasm and single-pass type I membrane protein. TREML1 / TLT-1 is expressed exclusively in platelets and megakaryocytes (MKs) and that its expression is up-regulated dramatically upon platelet activation. It is a receptor that may play a role in the innate and adaptive immune response. TREML1 / TLT-1 contains the characteristic single V-set immunoglobulin (Ig) domain, its longer cytoplasmic tail is composed of both a proline-rich region and an immune receptor tyrosine-based inhibitory motif, the latter known to be used for interactions with protein tyrosine phosphatases. The triggering receptors expressed on myeloid cells (TREMs) have drawn considerable attention due to their ability to activate multiple cell types within the innate immune system, including neutrophils, monocyte / macrophages, and dendritic cells, via their association with DAP12. TREML1 / TLT-1 is prepackaged, along with CD62P, into both MK and platelet alpha-granules. Differences in thrombin-induced redistribution of CD62P and TREML1 indicate that TREML1 is not simply cargo of alpha-granules but may instead regulate granule construction or dispersal. TREML1 / TLT-1 does not function to inhibit members of the TREM family but instead may play a role in maintaining vascular hemostasis and regulating coagulation and inflammation at sites of injury. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human TLT-1 / TREML1 Protein (TMPY-01840) |
| Antigen Species | Human |
| Biology Area | ITIM/ITAM Immunoreceptors and Related Molecules |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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