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Anti-TLT-1/TREML1 Antibody (3P589)

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Catalog No. TMAY-02153
Alias UNQ1825/PRO3438, triggering receptor expressed on myeloid cells like 1, TLT-1, TLT1, PRO3438, MGC119173, GLTL1825, dJ238O23.3

Anti-TLT-1/TREML1 Antibody (3P589) is a Mouse antibody targeting TLT-1/TREML1. Anti-TLT-1/TREML1 Antibody (3P589) can be used in ELISA(Cap).

Anti-TLT-1/TREML1 Antibody (3P589)

Anti-TLT-1/TREML1 Antibody (3P589)

😃Good
Catalog No. TMAY-02153Alias UNQ1825/PRO3438, triggering receptor expressed on myeloid cells like 1, TLT-1, TLT1, PRO3438, MGC119173, GLTL1825, dJ238O23.3
Anti-TLT-1/TREML1 Antibody (3P589) is a Mouse antibody targeting TLT-1/TREML1. Anti-TLT-1/TREML1 Antibody (3P589) can be used in ELISA(Cap).
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20 μL$68 7-10 days
100 μL$198 7-10 days
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Product Introduction

Bioactivity
Description
Antibody Type: Mouse Monoclonal

Application: ELISA(Cap)

Reactivity: Human
AliasUNQ1825/PRO3438, triggering receptor expressed on myeloid cells like 1, TLT-1, TLT1, PRO3438, MGC119173, GLTL1825, dJ238O23.3
Ig Type
Mouse IgG1
Clone
3P589
Reactivity
Human
Application
ELISA(Cap)
Antibody Type
Monoclonal
Host SpeciesMouse
ConstructionThis antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human TLT-1 / TREML1 (rh TLT-1 / TREML1; TMPY-01840; Q86YW5-1; Met1-Pro162). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
PurificationProtein A
AppearanceLiquid
Formulation0.2 μm filtered solution in PBS
Research BackgroundTrem-like transcript 1 protein, also known as Triggering receptor expressed on myeloid cells-like protein 1, TREML1 and TLT-1, is a cytoplasm and single-pass type I membrane protein. TREML1 / TLT-1 is expressed exclusively in platelets and megakaryocytes (MKs) and that its expression is up-regulated dramatically upon platelet activation. It is a receptor that may play a role in the innate and adaptive immune response. TREML1 / TLT-1 contains the characteristic single V-set immunoglobulin (Ig) domain, its longer cytoplasmic tail is composed of both a proline-rich region and an immune receptor tyrosine-based inhibitory motif, the latter known to be used for interactions with protein tyrosine phosphatases. The triggering receptors expressed on myeloid cells (TREMs) have drawn considerable attention due to their ability to activate multiple cell types within the innate immune system, including neutrophils, monocyte / macrophages, and dendritic cells, via their association with DAP12. TREML1 / TLT-1 is prepackaged, along with CD62P, into both MK and platelet alpha-granules. Differences in thrombin-induced redistribution of CD62P and TREML1 indicate that TREML1 is not simply cargo of alpha-granules but may instead regulate granule construction or dispersal. TREML1 / TLT-1 does not function to inhibit members of the TREM family but instead may play a role in maintaining vascular hemostasis and regulating coagulation and inflammation at sites of injury.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Protein: Human TLT-1 / TREML1 Protein (TMPY-01840)
Antigen Species
Human
Biology Area
ITIM/ITAM Immunoreceptors and Related Molecules
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
TransportShipping with blue ice.

Sci Citations

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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