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Ervogastat

Name: Ervogastat
Brand: TargetMol
SKU: T9186
Price: 132 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9186Cas No. 2186700-33-2

Alias PF-06865571

Ervogastat (PF-06865571) is a potent and well-tolerated diacylglycerol acyltransferase 2 inhibitor. Ervogastat reduces steatosis and hepatic triglyceride levels in non-alcoholic steatohepatitis (NASH).

Ervogastat

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Purity: 99.97%

Catalog No. T9186Alias PF-06865571Cas No. 2186700-33-2

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$132	In Stock	In Stock
5 mg	$323	In Stock	In Stock
10 mg	$539	In Stock	In Stock
25 mg	$869	In Stock	In Stock
50 mg	$1,180	In Stock	In Stock
100 mg	$1,590	-	In Stock
1 mL x 10 mM (in DMSO)	$335	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.97%

Appearance:Solid

Color:White

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COA HPLC HNMR LCMS

Product Introduction

Ervogastat AI Summary

Ervogastat inhibits several key enzymes involved in lipid metabolism, such as DGAT2, MGAT1, MGAT2, and MGAT3, demonstrating high affinity and low IC50 values for triglyceride synthesis inhibition in hepatocytes. The compound shows good oral bioavailability in rats and monkeys, indicating potential for systemic circulation. It displays reversible inhibition of certain cytochrome P450 enzymes in liver microsomes with varying IC50 values, suggesting complex interactions with drug metabolism pathways. In in vivo studies, Ervogastat effectively reduces triglyceride levels in different rat models, highlighting its potential therapeutic effect on lipid metabolism disorders. Additionally, it exhibits antiviral activity against SARS-CoV-2, with an IC50 greater than 20000.0 nM, by inhibiting virus-induced cytotoxicity in VERO-6 cells after 48 hours of exposure..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Ervogastat (PF-06865571) is a potent and well-tolerated diacylglycerol acyltransferase 2 inhibitor. Ervogastat reduces steatosis and hepatic triglyceride levels in non-alcoholic steatohepatitis (NASH).
Synonyms	PF-06865571

Chemical Properties

Molecular Weight	407.42
Formula	C₂₁H₂₁N₅O₄
Cas No.	2186700-33-2
Smiles	O(C1=CC(C=2N=CC(C(N[C@H]3CCOC3)=O)=CN2)=CN=C1)C4=C(OCC)C=CC=N4
Relative Density.	1.36 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 120 mg/mL (294.54 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4545 mL	12.2723 mL	24.5447 mL	122.7235 mL
5 mM	0.4909 mL	2.4545 mL	4.9089 mL	24.5447 mL
10 mM	0.2454 mL	1.2272 mL	2.4545 mL	12.2723 mL
20 mM	0.1227 mL	0.6136 mL	1.2272 mL	6.1362 mL
50 mM	0.0491 mL	0.2454 mL	0.4909 mL	2.4545 mL
100 mM	0.0245 mL	0.1227 mL	0.2454 mL	1.2272 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc