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Betahistine

Name: Betahistine
Brand: TargetMol
SKU: T4195
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4195Cas No. 5638-76-6

Alias Vasomotal, Serc base, PT 9 base

Betahistine (Vasomotal) is a histamine analog and H1 receptor agonist that serves as a vasodilator. It is used in MENIERE DISEASE and in vascular headaches but may exacerbate bronchial asthma and peptic ulcers. Betahistine dihydrochloride is an anti-vertigo drug. It is commonly prescribed for balance disorders or to alleviate vertigo symptoms associated with Ménière's disease.

Betahistine

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Purity: 99.87%

Catalog No. T4195Alias Vasomotal, Serc base, PT 9 baseCas No. 5638-76-6

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
100 mg	$30	-	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.87%

Resource Download

COA HNMR LCMS

Product Introduction

Betahistine AI Summary

Betahistine exhibits a contractile effect on isolated guinea pig ileal segments, indicating H1 receptor agonistic activity with a relative activity of 8.0% compared to histamine. It also has a binding affinity to the rat histamine H3 receptor with a Ki value of 2030.0 nM. The compound appears to pose a low risk of causing drug-induced liver injury, as assay results for multiple hepatic side effects yield a combined score of 0.0, suggesting minimal liver toxicity. Additionally, Betahistine affects various organ system functions and metabolic parameters, including liver and kidney function markers, electrolyte balance, and hematological parameters. It shows antiviral activity against SARS-CoV-2 with a hit score of 0.1802 in HRCE cells and an IC50 value greater than 20000.0 nM for cytotoxicity inhibition in VERO-6 cells, indicating moderate to weak antiviral efficacy. Furthermore, the compound did not exhibit significant inhibition or binding affinity for other tested targets in in vitro assays, with AC50 values greater than 30000.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Betahistine (Vasomotal) is a histamine analog and H1 receptor agonist that serves as a vasodilator. It is used in MENIERE DISEASE and in vascular headaches but may exacerbate bronchial asthma and peptic ulcers. Betahistine dihydrochloride is an anti-vertigo drug. It is commonly prescribed for balance disorders or to alleviate vertigo symptoms associated with Ménière's disease.
Synonyms	Vasomotal, Serc base, PT 9 base

Chemical Properties

Molecular Weight	136.19
Formula	C₈H₁₂N₂
Cas No.	5638-76-6
Smiles	CNCCC1=NC=CC=C1
Relative Density.	0.984 g/cm3. Temperature:25 °C.

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 30 mg/mL (220.28 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (14.69 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	7.3427 mL	36.7134 mL	73.4268 mL	367.1342 mL
5 mM	1.4685 mL	7.3427 mL	14.6854 mL	73.4268 mL
10 mM	0.7343 mL	3.6713 mL	7.3427 mL	36.7134 mL
20 mM	0.3671 mL	1.8357 mL	3.6713 mL	18.3567 mL
50 mM	0.1469 mL	0.7343 mL	1.4685 mL	7.3427 mL
100 mM	0.0734 mL	0.3671 mL	0.7343 mL	3.6713 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc