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Fipamezole (Synonyms: JP-1730, JP1730, JP 1730, BVF-025)

Name: Fipamezole
Brand: TargetMol
SKU: T24064
Price: 377 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T24064 Copy Product Info

Purity: 99.97%

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Fipamezole is a potent alpha2 adrenergic receptor antagonist that may be useful for studying autonomic dysfunction in Parkinson's disease.

Fipamezole

Copy Product Info

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Catalog No. T24064

Synonyms JP-1730, JP1730, JP 1730, BVF-025

Fipamezole is a potent alpha2 adrenergic receptor antagonist that may be useful for studying autonomic dysfunction in Parkinson's disease.

Cas No. 150586-58-6

Pack Size	Price	USA Stock	Global Stock
1 mg	$377	In Stock	In Stock
5 mg	$810	In Stock	In Stock
10 mg	$913	In Stock	In Stock
25 mg	$1,060	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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Custom-made molecule. TargetMol’s expert synthesis team delivers cost-effective solutions. Contact us for inquiries. Committed to serving you.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.97%

Appearance:Solid

Color:White to Yellow

Resource Download

COA LCMS FNMR HNMR

Product Introduction

Fipamezole AI Summary

Fipamezole demonstrates significant antihypothermic activity in NMRI mice when administered either orally (po) or intraperitoneally (ip), effectively inhibiting guanabenz-induced hypothermia. It has an ED50 of 1.87 mg/kg for oral administration and 0.47 mg/kg for intraperitoneal administration. This compound displaces [3H]-RX821002 from adrenergic alpha2B and alpha-2C receptors with Ki values of 6.761 nM and 13.8 nM, respectively, and acts as an antagonist at the adrenergic alpha2A receptor with a pKb value of 7.84. Additionally, Fipamezole displaces [3H]-prazosin from the adrenergic alpha-1b receptor with a Ki value of 2089.3 nM. At a dose of 10 mg/kg intraperitoneally, it increases normetanephrine levels in the mouse cortex by 247.0% following microwave irradiation..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Fipamezole is a potent alpha2 adrenergic receptor antagonist that may be useful for studying autonomic dysfunction in Parkinson's disease.
Targets&IC50	α2B-adrenoceptor (human):17 nM (Ki), α2C-adrenoceptor (human):55 nM (Ki), α2A-adrenoceptor (human):9.2 nM (Ki)
Synonyms	JP-1730, JP1730, JP 1730, BVF-025

Chemical Properties

Molecular Weight	230.28
Formula	C₁₄H₁₅FN₂
Cas No.	150586-58-6
Smiles	C(C)C1(CC=2C(C1)=CC=C(F)C2)C3=CN=CN3
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (238.84 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.3425 mL	21.7127 mL	43.4254 mL	217.1270 mL
5 mM	0.8685 mL	4.3425 mL	8.6851 mL	43.4254 mL
10 mM	0.4343 mL	2.1713 mL	4.3425 mL	21.7127 mL
20 mM	0.2171 mL	1.0856 mL	2.1713 mL	10.8563 mL
50 mM	0.0869 mL	0.4343 mL	0.8685 mL	4.3425 mL
100 mM	0.0434 mL	0.2171 mL	0.4343 mL	2.1713 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc