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Anti-CHGA Monoclonal Antibody-Biotin is a biotin-conjugated humanized rabbit antibody targeting CHGA. Anti-CHGA Monoclonal Antibody-Biotin can be used in ELISA,FCM.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 μg | $196 | 12 days | 12 days | |
| 50 μg | $236 | 12 days | 12 days | |
| 100 μg | $330 | 12 days | 12 days |
| Description | Anti-CHGA Monoclonal Antibody-Biotin is a biotin-conjugated humanized rabbit antibody targeting CHGA. Anti-CHGA Monoclonal Antibody-Biotin can be used in ELISA,FCM. |
| Synonyms | Pituitary secretory protein I, Chromogranin-A |
| Ig Type | Rabbit monoclonal IgG |
| Reactivity | Human |
| Verified Activity | Flow cytometry analysis of CHGA overexpressed 486F cells with TMAZ-0139B, followed by goat anti-rabbit IgG-ABflo 647 (red line). The isotype control is rabbit IgG (black line). |
| Application | |
| Recommended Dose | 0.1-0.2 μg/10E6 cells for FCM; 1 ng/μl for ELISA |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Single-pass type I membrane |
| Construction | This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of CHGA protein. |
| Purification | Protein A Affinity Purified |
| Appearance | Liquid |
| Formulation | 0.22 μm filtered solution in PBS. |
| Purity | > 95% as determined by SDS-PAGE. |
| Research Background | Strongly inhibits glucose induced insulin release from the pancreas|Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist (PubMed: 15326220). Displays antibacterial activity against Gram-positive bacteria S.aureus and M.luteus, and Gram-negative bacteria E.coli and P.aeruginosa (PubMed: 15723172, PubMed: 24723458). Can induce mast cell migration, degranulation and production of cytokines and chemokines (PubMed: 21214543). Acts as a potent scavenger of free radicals in vitro (PubMed: 24723458). May play a role in the regulation of cardiac function and blood pressure (PubMed: 18541522)|Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation |
| Conjucates | Biotin |
| Others Formats | Unconjugated |
| Antibody Types Available | 2 |
| Immunogen | CHGA |
| Antigen Species | Human |
| Gene ID | |
| Uniprot ID | |
| Biology Area | Cancer Research |
| Molecular Weight | 150 kDa |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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