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Gintemetostat

Name: Gintemetostat
Brand: TargetMol
SKU: T202312
Rating: 4.5 (1 reviews)

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Catalog No. T202312Cas No. 2604513-16-6

Alias NSD2-IN-1, KTX-1001, KTX1001

Gintemetostat (KTX-1001) is a potent and selective small molecule inhibitor of nuclear receptor-binding SET domain protein 2 (NSD2), exhibiting IC50 values ranging from 0.001 μM to 0.01 μM, and it belongs to the chemical class of piperidinyl-methyl-purineamine derivatives, with primary research applications in oncology for the treatment of NSD2-dysregulated cancers.

Gintemetostat

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Catalog No. T202312Alias NSD2-IN-1, KTX-1001, KTX1001Cas No. 2604513-16-6

Pack Size	Price	Availability
5 mg	$446	7-10 days
10 mg	$668	10-14 weeks
50 mg	Inquiry	10-14 weeks

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Product Introduction

Bioactivity

Description	Gintemetostat (KTX-1001) is a potent and selective small molecule inhibitor of nuclear receptor-binding SET domain protein 2 (NSD2), exhibiting IC50 values ranging from 0.001 μM to 0.01 μM, and it belongs to the chemical class of piperidinyl-methyl-purineamine derivatives, with primary research applications in oncology for the treatment of NSD2-dysregulated cancers.
Synonyms	NSD2-IN-1, KTX-1001, KTX1001

Chemical Properties

Molecular Weight	546.52
Formula	C₂₅H₂₆F₄N₈O₂
Cas No.	2604513-16-6
Smiles	C(C=1C(=CN=C(C1)C2=C(F)C=C(OC)C(F)=C2)N3C[C@]([C@@H](C(F)F)O)(N)CCC3)N4C=5C(N=C4)=C(N)N=CN5

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (146.38 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8298 mL	9.1488 mL	18.2976 mL	91.4880 mL
5 mM	0.3660 mL	1.8298 mL	3.6595 mL	18.2976 mL
10 mM	0.1830 mL	0.9149 mL	1.8298 mL	9.1488 mL
20 mM	0.0915 mL	0.4574 mL	0.9149 mL	4.5744 mL
50 mM	0.0366 mL	0.1830 mL	0.3660 mL	1.8298 mL
100 mM	0.0183 mL	0.0915 mL	0.1830 mL	0.9149 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc