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CFTR

CFTR, a 12TM, ABC transporter-type protein, is a cAMP-regulated epithelial cell membrane Cl- channel involved in normal fluid transport across various epithelia.

  • Elexacaftor
    T149352216712-66-0
    Elexacaftor (VX-445) is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR) and it also facilitates the processing and trafficking of CFTR to increase the amount of CFTR at the cell surface.
    • $89
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  • Glucosamine
    T04293416-24-8
    Glucosamine (Chitosamine) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Supplemental glucosamine may help to rebuild cartilage and treat arthritis.
    • $50
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  • VRT-532
    T2911438214-71-0In house
    VRT-532 (CFpot-532) is an effective modulator of CFTR and is commonly used in studies of cystic fibrosis (CF) caused by CFTR defects. Arylsulfatase B (ARSB), which is necessary to reduce the accumulation of sulphate glycosaminosaccharide (gag) in cystic fibrosis, and modification of CFTR by small molecule modulator VRT-532 can increase ARSB and reduce the accumulation of 4-chondroitin sulfate.
    • $197
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  • WAY-326766
    T77604853138-67-7
    WAY-326766 increases ion transport through mutant CFTR and can be used to alter the lifespan of eukaryotes.WAY-326766 can be used to treat cystic fibrosis (CF).
    • $72
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  • Bamocaftor
    T302932204245-48-5In house
    Bamocaftor is a CFTR channel (DeltaF508-CFTR mutation) corrector for CF transmembrane conductance regulators designed to restore F508del-CFTR protein function. Combined use of tezacaftor and VX-561 for the treatment of cystic fibrosis patients with F508del/MF.
    • $372
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  • CFTR corrector 4
    T107761918142-34-3In house
    CFTR corrector 4 is a potent and orally available transmembrane conductance regulator (CFTR) for cystic fibrosis and is a potent (R,R) type active enantiomer. CFTR corrector 4 increases CFTR levels on the cell surface and is a potential compound for the study of cystic fibrosis.
    • $68
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  • Cavosonstat
    T269551371587-51-7In house
    Cavosonstat (N91115) is an orally active S-nitrosoglutathione reductase (GSNOR) inhibitor that promotes cystic fibrosis transmembrane conductance regulator (CFTR) maturation and plasma membrane stabilization.Cavosonstat is a CFTR stabilizer and can be used to study cystic fibrosis.
    • $73
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  • CFTR corrector 8
    T638061918142-35-4In house
    CFTR corrector 8 is a highly effective modulator of the cystic fibrosis transmembrane conductance regulator (CFTR). This compound is specifically designed for utilization in research related to cystic fibrosis, a genetic disorder primarily affecting the lungs and digestive system [1].
    • $272
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  • BPO-27 racemate
    T105911314873-02-3In house
    BPO-27 racemate (BPO-27 (racemate)) is an effective CFTR inhibitor with IC50 of 8 nM.
    • $68
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  • CFTR corrector 12
    T79578958941-60-1
    CFTR corrector 12 is a CFTR corrector that rescues all mutant proteins except M760R ABCA3, and can be used to study cystic fibrosis.
    • $195 TargetMol
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  • CFTR(inh)-172
    T2355307510-92-5
    CFTR(inh)-172 (CFTR Inhibitor-172) is a voltage-independent, selective CFTR inhibitor.
    • $30
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    TargetMol | Citations Cited
  • Lumacaftor
    T2595936727-05-8
    Lumacaftor (VRT 826809) is a CFTR modulator that corrects the folding and trafficking of CFTR protein. It enhances F508del-CFTR protein maturation in FRT cells (EC50: 100 nM).
    • $43
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    TargetMol | Citations Cited
  • GlyH-101
    T2451328541-79-3
    GlyH-101 is a cell-permeable glycinyl hydrazone compound that blocks CFTR with Ki of 1.4 uM.
    • $34
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  • Glibenclamide
    T163410238-21-8
    Glibenclamide (Glyburide) is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.
    • $45
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  • Tezacaftor
    T22631152311-62-0
    Tezacaftor (VX661) is a small molecule that can be used as a corrector of the cystic fibrosis transmembrane conductance regulator (CFTR) gene function.
    • $34
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  • Ivacaftor
    T2588873054-44-5
    Ivacaftor (VX-770) (VX-770) is a potentiator of CFTR targeting G551D-CFTR (EC50: 100 nM) and F508del-CFTR (EC50: 25 nM) in Fisher rat thyroid cells, respectively.
    • $32
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    TargetMol | Citations Cited
  • Icenticaftor
    T94991334546-77-8
    Icenticaftor (QBW251) is an orally active potentiator of CFTR channel.
    • $373
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  • CFTR corrector 2
    T53121628416-28-3
    CFTR corrector 2 (FDL169) is a novel and potent CFTR (Cystic fibrosis transmembrane conductance regulator) corrector for treating cystic fibrosis (CF) patients who carry the F508del mutation.
    • $39
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  • SRI-37240
    T61702883956-47-6
    SRI-37240 is a potent inhibitor of premature termination codons (PTCs) with read-across activity that induces a prolonged pause at the termination codon and inhibits PTCs associated with cystic fibrosis.SRI-37240 can be used to study PTC-related diseases.
    • $35
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  • (R)-Elexacaftor
    T782402229860-99-3
    (R)-Elexacaftor, an enantiomer of Elexacaftor, functions as a modulator of the cystic fibrosis transmembrane conductance regulator (CFTR). It exhibits an EC50 of 0.29 µM for the CFTR dF508 mutation [1].
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  • CFTR corrector 9
    T60653909861-78-5
    CFTR Corrector 9, a cystic fibrosis transmembrane conductance regulator (CFTR) modulator, is employed in the research of cystic fibrosis (CF) and related CFTR-associated disorders [1].
    • $41
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  • GLPG1837
    T70831654725-02-6
    GLPG1837 (ABBV-974) is an effective CFTR potentiator, with EC50s of 3 nM and 339 nM for F508del and G551D CFTR, respectively.
    • $54
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  • CRF1 receptor antagonist-1
    T797932635364-30-4
    CRF1 Receptor Antagonist-1 (Compound 2), a CRF1 receptor antagonist, is utilized in research pertaining to congenital adrenal hyperplasia (CAH) [1].
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  • PG01
    T16516853138-65-5
    PG01 is a potent CFTR Cl-channel potentiator, effective against ΔF508 (Ka 0.3 μM), and also against E193K, G970R and G551D (CFTR mutants), with Kd values of 0.22 μM, 0.45 μM and 1.94 μM, respectively.PG01 increases ΔF508-CFTR Cl- currents upon addition of forskolin. F508-CFTR Cl-current upon addition of Forskolin, correcting the gating defect of CFTR mutants.
    • $126
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  • KM11060
    T3135774549-97-2
    KM11060 is a novel corrector of the F508del-CFTR trafficking defect, Correcting F508del-CFTR trafficking, increasing the amount of functional CFTR at the plasma membrane.
    • $47
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  • IOWH-032
    T24861191252-49-9
    IOWH-032 (IOWH032) , a synthetic CFTR inhibitor, has been investigated for the treatment of cholera, diarrhea, and secretory diarrhea.
    • $54
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  • Ataluren
    T1805775304-57-9
    Ataluren (PTC124) is a novel, orally administered drug that targets nonsense mutations. Ataluren is approved for use by the European Medicines Agency to treat Duchenne Muscular Dystrophy in patients aged 5 years and older who are able to walk.
    • $32
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  • Nesolicaftor
    T166811953130-87-4
    Nesolicaftor (PTI-428) specifically enhances cystic fibrosis transmembrane conductance regulator protein synthesis.
    • $97
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  • DNDS
    T203413709-43-1
    DNDS is a channel blocker of voltage-dependent cystic fibrosis transmembrane conductance regulator (CFTR).
    • $29
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  • UCCF-853
    T29041625458-06-2
    UCCF-853 is a small-molecule CFTR modulator that can be used to study cystic fibrosis.
    • $32
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  • (R)-BPO-27
    T10591L1415390-47-4
    (R)-BPO-27 is an orally active and potent ATP-competitive CFTR inhibitor (IC50: 4 nM) for the study of diarrhoea and polycystic kidney.
    • $275
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  • PPQ-102
    T1874931706-15-9
    PPQ-102 (CFTR Inhibitor), an effective CFTR inhibitor, can completely inhibit CFTR chloride current (IC50: 90 nM).
    • $34
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