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HCN Channel

Hyperpolarization-activated cyclic nucleotide–gated (HCN) channels are integral membrane proteins that serve as nonselective voltage-gated cation channels in the plasma membranes of heart and brain cells. HCN channels are sometimes referred to as pacemaker channels because they help to generate rhythmic activity within groups of heart and brain cells. HCN channels are activated by membrane hyperpolarization, are permeable to Na+ and K+, and are constitutively open at voltages near the resting membrane potential.[2] HCN channels are encoded by four genes (HCN1, 2, 3, 4) and are widely expressed throughout the heart and the central nervous system.

RO-275
T873392648837-04-9
RO-275 is a selective HCN1 inhibitor with oral activity, also inhibiting HCN2, HCN3, and HCN4. It improves working memory and is used in research on cognitive disorders.
  • $173
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Zatebradine hydrochloride
T13387L91940-87-3
Zatebradine hydrochloride (UL-FS-49CL) is a highly effective and effective HCN Channel inhibitor (IC50:1.96 µM). HCN Channel is an effective hyperpolarization activated loop nucleotide gated channel. Zatebradine hydrochloride blocks slow inward currents through human HCN1, HCN2, HCN3, and HCN4 channels with IC50 values of 1.83 µM, 2.21 µM, 1.90 µM, and 1.88 µM, respectively.
  • $45
In Stock
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ZD7288
T7516133059-99-1
ZD7288 (ICI D7288), a selective hyperpolarization-activated cyclic nucleotide-gated channel blocker, inhibits hippocampal synaptic plasticity.
  • $30
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TargetMol | Citations Cited
Ivabradine hydrochloride
T2535148849-67-6
Ivabradine hydrochloride (S 16257-2) is a new If inhibitor (IC50: 2.9 μM). Ivabradine Hydrochloride is the hydrochloride salt form of ivabradine, an orally bioavailable, hyperpolarization-activated, cyclic nucleotide-gated (HCN) channel blocker, with negative chronotropic activity. Upon administration, ivabradine selectively binds to the intracellular portion of the HCN channel pore and blocks HCN channels in the pacemaker cells within the sinoatrial (SA) node. This inhibits the If (funny) pacemaker ion current, prevents the inward flow and intracellular accumulation of positively charged ions, reduces pacemaker activity and slows diastolic depolarization.
  • $33
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Alinidine
T8398033178-86-8In house
Alinidine is an HCN channel blocker with antiarrhythmic effects and can be used for the study of angina pectoris.
  • $195
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Cilobradine hydrochloride
T10813186097-54-1
Cilobradine hydrochloride (DK-AH 269) is an HCN Channel blocker and an open channel blocker of neuronal Ih and related cardiac If channels.
  • $37
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TargetMol | Inhibitor Sale
BPU-11
T23818909664-41-1
Fenchyl alcohol is a monoterpene alcohol extracted from the essential oil of Douglas fir leaves and used as a flavor. It significantly inhibits the activity of rumen microorganisms in sheep and deer.
  • $31
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TargetMol | Inhibitor Sale
MS7710
T207039
MS7710 is a brain-penetrant inhibitor of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels. It reduces Ih current by inhibiting HCN channels, thereby decreasing the activity of dopamine neurons in the ventral tegmental area (VTA). MS7710 effectively improves social interaction deficits and reward-related cognitive flexibility in mouse models of chronic social defeat stress (CSDS) and shows promise for depression research.
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Zatebradine
T1338785175-67-3
Zatebradine is a potent hyperpolarization-activated cyclic nucleotide-gated (HCN) channels inhibitor(IC50 of 1.96 µM).
  • $88
5 days
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Ivabradine
T63014155974-00-8
Ivabradine is a potent, orally active HCN (hyperpolarization-activated cyclic nucleotide-gated) channel blocker that inhibits pacemaker current (If). ivabradine decreases heart rate in a dose-dependent manner and does not alter blood pressure. ivabradine has anticonvulsant, anti-ischaemic and anti-anginal effects.
  • $2,140
6-8 weeks
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KIO-301 chloride
T867831643463-59-5
KIO-301 chloride, an azobenzene photoswitch compound, inhibits voltage-gated ion channels, such as hyperpolarisation-activated cyclic nucleotide-gated (HCN) channels and voltage-gated potassium channels, upon exposure to visible light [1].
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    pan-HCN-IN-1
    T870981334308-63-2
    Pan-HCN-IN-1 (Compound J&J12e) is an inhibitor of the hyperpolarization-activated and cyclic-nucleotide-gated 1 (HCN1) ion channel, with an IC50 of 58 nM. Pan-HCN-IN-1 reduces the voltage sag response and enhances EPSP summation in ex vivo rat brain slices [1].
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    10-14 weeks
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    8-Pcpt-cGMP sodium
    T8814251239-26-0
    8-Pcpt-cGMP sodium, with an EC50 of 0.5 μM, acts as an agonist for cyclic nucleotide-gated (CNG) channels and demonstrates effective membrane permeability. This compound is utilized in research focused on the role of CNG channels in visual and olfactory signal transduction.
    • $1,520
    4-6 weeks
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    Sp-8-Br-cGMPS
    T88734153660-03-8
    Sp-8-Br-cGMPS, an analogue of cGMP, acts as an agonist for cGMP gated cation channels (CNG channels) with an EC50 of 106.5 μM. While Sp-8-Br-cGMPS can induce currents, it does not stabilize channel open states as effectively as a full agonist.
    • $1,970
    10-14 weeks
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    8-Pcpt-cGMP
    T8870254364-02-2
    8-Pcpt-cGMP acts as an agonist for cyclic nucleotide-gated (CNG) channels with an EC50 of 0.5 μM and exhibits good membrane permeability. This compound is utilized in research to explore the role of CNG channels in visual and olfactory signal transduction.
    • $1,520
    8-10 weeks
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